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Wenhui Hu

A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
2007 · Lenka Munoz, Hantamalala Ralay Ranaivo, et al. · Journal of Neuroinflammation · 224
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Disulfiram suppresses NLRP3 inflammasome activation to treat peritoneal and gouty inflammation
2020 · Wenmin Deng, Zhongjin Yang, et al. · Free Radical Biology and Medicine · 103
Development of a novel therapeutic suppressor of brain proinflammatory cytokine up-regulation that attenuates synaptic dysfunction and behavioral deficits
2006 · Wenhui Hu, Hantamalala Ralay Ranaivo, et al. · Bioorganic & Medicinal Chemistry Letters · 66
Design and synthesis of pinanamine derivatives as anti-influenza A M2 ion channel inhibitors
2012 · Xin Zhao, Yanling Jie, et al. · Antiviral Research · 55
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes
2010 · Jifeng Deng, Li Peng, et al. · European Journal of Medicinal Chemistry · 54
Imidazole-based pinanamine derivatives: Discovery of dual inhibitors of the wild-type and drug-resistant mutant of the influenza A virus
2015 · Jianghong Dong, Shengwei Chen, et al. · European Journal of Medicinal Chemistry · 47
Identification of Hits as Matrix-2 Protein Inhibitors through the Focused Screening of a Small Primary Amine Library
2010 · Wenhui Hu, Shaogao Zeng, et al. · Journal of Medicinal Chemistry · 44
Tanshinones inhibit NLRP3 inflammasome activation by alleviating mitochondrial damage to protect against septic and gouty inflammation
2021 · Hu Yue, Zhongjin Yang, et al. · International Immunopharmacology · 40
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
2012 · Hui Xie, Lili Zeng, et al. · European Journal of Medicinal Chemistry · 39
Optimized POCl3-assisted synthesis of 2-amino-1,3,4-thiadiazole/1,3,4-oxadiazole derivatives as anti-influenza agents
2022 · Jianghong Dong, Qinglan Pei, et al. · Arabian Journal of Chemistry · 38
P4–428: Glia as a therapeutic target: Selective suppression of human amyloid–beta–induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
2006 · Linda J. Van Eldik, Hanta Ralay Ranaivo, et al. · Alzheimer s & Dementia · 34
Discovery of Highly Potent Pinanamine-Based Inhibitors against Amantadine- and Oseltamivir-Resistant Influenza A Viruses
2018 · Xin Zhao, Runfeng Li, et al. · Journal of Medicinal Chemistry · 33
Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer’s Disease Models
2016 · Wei Zhou, Guifa Zhong, et al. · ACS Chemical Neuroscience · 31
Anti-Neuroinflammatory Agents for the Treatment of Alzheimer’s Disease
2013 · Wei Zhou, Wenhui Hu · Future Medicinal Chemistry · 31
Aminopyridazines Attenuate Hippocampus-Dependent Behavioral Deficits Induced by Human β-Amyloid in a Murine Model of Neuroinflammation
2004 · Jeffrey M. Craft, Linda J. Van Eldik, et al. · Journal of Molecular Neuroscience · 31
Discovery of chalcone analogues as novel NLRP3 inflammasome inhibitors with potent anti-inflammation activities
2021 · Cheng Zhang, Hu Yue, et al. · European Journal of Medicinal Chemistry · 30
Bortezomib inhibits NLRP3 inflammasome activation and NF-κB pathway to reduce psoriatic inflammation
2022 · Xiuhui Chen, Yanhong Chen, et al. · Biochemical Pharmacology · 25
Cappariloside A shows antiviral and better anti-inflammatory effects against influenza virus via regulating host IFN signaling, in vitro and vivo
2018 · Zhengtu Li, Junling Zhao, et al. · Life Sciences · 21
Discovery of a Novel Oral Proteasome Inhibitor to Block NLRP3 Inflammasome Activation with Anti-inflammation Activity
2022 · Xinyi Wu, Ping Sun, et al. · Journal of Medicinal Chemistry · 20
Seratrodast, a thromboxane A2 receptor antagonist, inhibits neuronal ferroptosis by promoting GPX4 expression and suppressing JNK phosphorylation
2022 · Ying Hao, Yitao Ou, et al. · Brain Research · 20
Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization
2013 · Hui Xie, Lili Zeng, et al. · European Journal of Medicinal Chemistry · 20
Molecular Properties and CYP2D6 Substrates: Central Nervous System Therapeutics Case Study and Pattern Analysis of a Substrate Database
2009 · Laura K. Chico, Heather A. Behanna, et al. · Drug Metabolism and Disposition · 20
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Small molecules targeting Pin1 as potent anticancer drugs
2023 · Jing Zhang, Wenwen Zhou, et al. · Frontiers in Pharmacology · 19
AD-16 Protects Against Hypoxic-Ischemic Brain Injury by Inhibiting Neuroinflammation
2022 · Zhihua Huang, Zhengwei Luo, et al. · Neuroscience Bulletin · 19
Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome
2020 · Yitao Ou, Ping Sun, et al. · Bioorganic & Medicinal Chemistry Letters · 19
Works count: 62
Citation count: 1,340
H-index: 20
I10-index: 38
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