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Author

Jian Chen

Observed institutions: The University of Texas MD Anderson Cancer Center, China Medical University, Hokkaido University, University of Alabama at Birmingham, Magee-Womens Research Institute, UPMC Hillman Cancer Center, Chi Mei Medical Center, First Hospital of China Medical University, Hadassah, Shanghai Municipal Center For Disease Control Prevention, Celgene (United States), UAB Medicine, State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, Institute for Genetic Medicine, Hokkaido University, Zhejiang University, China Medical University
ORCID: 0000-0003-1090-5586
Observed ORCIDs: 0000-0003-1090-5586, 0000-0001-5230-7141, 0000-0001-8105-3670
OpenAlex ID: A5100727841
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
2017 · Adrian Ally, Miruna Balasundaram, et al. · Cell · 2,613
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Immunomodulatory TGF-β Signaling in Hepatocellular Carcinoma
2019 · Jian Chen, Julian A. Gingold, et al. · Trends in Molecular Medicine · 278
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Targeting TGF-β signaling in cancer
2013 · Lior H Katz, Ying Li, et al. · Expert Opinion on Therapeutic Targets · 219
Aurora B kinase phosphorylates and instigates degradation of p53
2012 · Chris P. Gully, Guermarie Velazquez-Torres, et al. · Proceedings of the National Academy of Sciences · 197
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A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily
2018 · Anil Korkut, Sobia Zaidi, et al. · Cell Systems · 189
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Dominant-Negative Hypoxia-Inducible Factor-1α Reduces Tumorigenicity of Pancreatic Cancer Cells through the Suppression of Glucose Metabolism
2003 · Jian Chen, Songji Zhao, et al. · American Journal Of Pathology · 172
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Analysis of Genomes and Transcriptomes of Hepatocellular Carcinomas Identifies Mutations and Gene Expression Changes in the Transforming Growth Factor-β Pathway
2017 · Jian Chen, Sobia Zaidi, et al. · Gastroenterology · 145
Effects of Obesity on Transcriptomic Changes and Cancer Hallmarks in Estrogen Receptor–Positive Breast Cancer
2014 · Enrique Fuentes-Mattei, Guermarie Velazquez-Torres, et al. · JNCI Journal of the National Cancer Institute · 121
Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers
2011 · Ruiying Zhao, Sai-Ching J. Yeung, et al. · Journal of Clinical Investigation · 111
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Antineoplastic effects of an Aurora B kinase inhibitor in breast cancer
2010 · Christopher P Gully, Fanmao Zhang, et al. · Molecular Cancer · 106
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Hypoxia-Mediated Up-Regulation of Pim-1 Contributes to Solid Tumor Formation
2009 · Jian Chen, Masanobu Kobayashi, et al. · American Journal Of Pathology · 98
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Roles for CSN5 in control of p53/MDM2 activities
2007 · Xiao‐Chun Zhang, Jian Chen, et al. · Journal of Cellular Biochemistry · 89
The cell cycle regulator 14-3-3σ opposes and reverses cancer metabolic reprogramming
2015 · Liem Phan, Ping-Chieh Chou, et al. · Nature Communications · 86
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The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth
2010 · Yin-Hsun Feng, Guermarie Velazquez-Torres, et al. · Journal of Cellular and Molecular Medicine · 85
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Epigenetic Reprogramming of HOXC10 in Endocrine-Resistant Breast Cancer
2014 · Thushangi N. Pathiraja, Shweta R. Nayak, et al. · Science Translational Medicine · 78
Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers
2018 · Julian A. Gingold, Dandan Zhu, et al. · Trends in Molecular Medicine · 73
CSN6 drives carcinogenesis by positively regulating Myc stability
2014 · Jian Chen, Ji-Hyun Shin, et al. · Nature Communications · 72
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IL6‐mediated inflammatory loop reprograms normal to epithelial‐mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta–deficient β2‐spectrin+/− mice
2016 · Abhisek Mitra, Jun Yan, et al. · Hepatology · 68
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14-3-3σ Exerts Tumor-Suppressor Activity Mediated by Regulation of COP1 Stability
2010 · Chun-Hui Su, Ruiying Zhao, et al. · Cancer Research · 57
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Vitamin D Deficiency Promotes Liver Tumor Growth in Transforming Growth Factor-β/Smad3-Deficient Mice Through Wnt and Toll-like Receptor 7 Pathway Modulation
2016 · Jian Chen, Lior H. Katz, et al. · Scientific Reports · 48
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TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome
2016 · Jian Chen, Zhi-Xing Yao, et al. · Journal of Clinical Investigation · 48
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Nuclear export regulation of COP1 by 14-3-3σ in response to DNA damage
2010 · Chun-Hui Su, Ruiying Zhao, et al. · Molecular Cancer · 47
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Origin and role of hepatic myofibroblasts in hepatocellular carcinoma
2020 · Betul Gok Yavuz, Roberto Carmagnani Pestana, et al. · Oncotarget · 42
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A Role for Histone H2B Variants in Endocrine-Resistant Breast Cancer
2015 · Shweta R Nayak, Emily Harrington, et al. · Hormones and Cancer · 41
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Loss of the transforming growth factor‐β effector β2‐Spectrin promotes genomic instability
2016 · Jian Chen, Vivek Shukla, et al. · Hepatology · 40
Works count: 111
Citation count: 5,335
H-index: 28
I10-index: 34
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