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Jiazhi Sun

Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice.
2003 · Michelle A Blaskovich, Jiazhi Sun, et al. · PubMed · 567
Ras CAAX Peptidomimetic FTI-277 Selectively Blocks Oncogenic Ras Signaling by Inducing Cytoplasmic Accumulation of Inactive Ras-Raf Complexes
1995 · Edwina C. Lerner, Yimin Qian, et al. · Journal of Biological Chemistry · 361
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Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
2005 · Jiazhi Sun, Michelle A Blaskovich, et al. · Oncogene · 264
Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts
1998 · Jiazhi Sun, Yimin Qian, et al. · Oncogene · 231
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.
1995 · J Sun, Y Qian, et al. · PubMed · 227
Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.
1999 · J Sun, M A Blaskovich, et al. · PubMed · 210
Both Farnesylated and Geranylgeranylated RhoB Inhibit Malignant Transformation and Suppress Human Tumor Growth in Nude Mice
2000 · Zhi Chen, Jiazhi Sun, et al. · Journal of Biological Chemistry · 198
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The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner
1997 · Andreas Vogt, Jiazhi Sun, et al. · Journal of Biological Chemistry · 190
Akt Mediates Ras Downregulation of RhoB, a Suppressor of Transformation, Invasion, and Metastasis
2004 · Kun Jiang, Jiazhi Sun, et al. · Molecular and Cellular Biology · 182
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Inhibition of Angiogenesis by Aβ Peptides
2004 · Daniel Paris, Kirk Townsend, et al. · Angiogenesis · 148
Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice
2000 · Michelle A. Blaskovich, Qing Lin, et al. · Nature Biotechnology · 143
GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells.
1997 · K Miquel, A Pradines, et al. · PubMed · 138
The BH3 α-Helical Mimic BH3-M6 Disrupts Bcl-XL, Bcl-2, and MCL-1 Protein-Protein Interactions with Bax, Bak, Bad, or Bim and Induces Apoptosis in a Bax- and Bim-dependent Manner
2010 · Aslamuzzaman Kazi, Jiazhi Sun, et al. · Journal of Biological Chemistry · 122
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Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
2005 · Jiazhi Sun, De-an Wang, et al. · Oncogene · 108
Disruption of the Rb-Raf-1 Interaction Inhibits Tumor Growth and Angiogenesis
2004 · Piyali Dasgupta, Jiazhi Sun, et al. · Molecular and Cellular Biology · 98
Bcl-XL-Templated Assembly of Its Own Protein−Protein Interaction Modulator from Fragments Decorated with Thio Acids and Sulfonyl Azides
2008 · Xiangdong Hu, Jiazhi Sun, et al. · Journal of the American Chemical Society · 76
Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice.
2003 · Jiazhi Sun, Junko Ohkanda, et al. · PubMed · 75
Prediction of Drug-Target Interactions for Drug Repositioning Only Based on Genomic Expression Similarity
2013 · Kejian Wang, Jiazhi Sun, et al. · PLoS Computational Biology · 72
Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor
2004 · Jiazhi Sun, Michelle A. Blaskovich, et al. · Cancer Research · 69
Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins
2009 · Jun Wei, Shinichi Kitada, et al. · Molecular Cancer Therapeutics · 62
The Geranylgeranyltransferase I Inhibitor GGTI-298 Induces Hypophosphorylation of Retinoblastoma and Partner Switching of Cyclin-dependent Kinase Inhibitors
1999 · Jiazhi Sun, Yimin Qian, et al. · Journal of Biological Chemistry · 58
Direct Tumor Lysis by NK Cells Uses a Ras-Independent Mitogen-Activated Protein Kinase Signal Pathway
2000 · Sheng Wei, Danielle L Gilvary, et al. · The Journal of Immunology · 55
Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone.
2002 · Lyudmila Burdelya, Robyn Catlett-Falcone, et al. · PubMed · 49
Investigation of the antifungal activity of the dicarboximide fungicide iprodione against Bipolaris maydis
2022 · Jiazhi Sun, Chaoyue Pang, et al. · Pesticide Biochemistry and Physiology · 29
Burkitt Lymphoma Daudi Cells Contain Two Distinct Farnesyltransferases with Different Divalent Cation Requirements
1995 · Andreas Vogt, Jiazhi Sun, et al. · Biochemistry · 22
Works count: 53
Citation count: 3,904
H-index: 24
I10-index: 33
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