Get started
Author

David J. Hughes

Observed names: D Hughes, D. Hughes, D.J. Hughes, David Hughes, David J Hughes, Hughes, David
ORCID: 0000-0002-7811-7263
Observed ORCID: 0000-0002-7811-7263
OpenAlex ID: A5101664027
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies
2018 · Collin D. Edington, Wen Li Kelly Chen, et al. · Scientific Reports · 502
PDF
3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection
2018 · A. M. Ortega-Prieto, J. K. Skelton, et al. · Nature Communications · 241
PDF
Integrated gut/liver microphysiological systems elucidates inflammatory inter‐tissue crosstalk
2017 · Wen L.K. Chen, Collin Edington, et al. · Biotechnology and Bioengineering · 172
PDF
Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease
2017 · Tomasz Kostrzewski, Terri Cornforth, et al. · World Journal of Gastroenterology · 153
PDF
Bioreactor technologies to support liver function in vitro
2014 · Mohammad R. Ebrahimkhani, Jaclyn A. Shepard Neiman, et al. · Advanced Drug Delivery Reviews · 141
Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological System
2016 · N. Tsamandouras, T. Kostrzewski, et al. · Journal of Pharmacology and Experimental Therapeutics · 121
PDF
Rapid production of human liver scaffolds for functional tissue engineering by high shear stress oscillation-decellularization
2017 · Giuseppe Mazza, Walid Al-Akkad, et al. · Scientific Reports · 110
PDF
Characterizing the reproducibility in using a liver microphysiological system for assaying drug toxicity, metabolism, and accumulation
2020 · Andrés Rubiano, Amruta Indapurkar, et al. · Clinical and Translational Science · 102
PDF
Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor
2015 · Ujjal Sarkar, Dinelia Rivera-Burgos, et al. · Drug Metabolism and Disposition · 96
A Microphysiological System for Studying Nonalcoholic Steatohepatitis
2019 · Tomasz Kostrzewski, Paloma Maraver, et al. · Hepatology Communications · 81
PDF
Integrated Assessment of Diclofenac Biotransformation, Pharmacokinetics, and Omics-Based Toxicity in a Three-Dimensional Human Liver-Immunocompetent Coculture System
2017 · Ujjal Sarkar, Kodihalli C. Ravindra, et al. · Drug Metabolism and Disposition · 72
PDF
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
2021 · Tomasz Kostrzewski, Sophie Snow, et al. · Communications Biology · 56
PDF
Perfused human hepatocyte microtissues identify reactive metabolite-forming and mitochondria-perturbing hepatotoxins
2017 · Cliff Rowe, Mohsen Shaeri, et al. · Toxicology in Vitro · 40
Organ-on-a-chip: current gaps and future directions.
2022 · Candarlioglu, Pelin L, Dal Negro, Gianni, et al. · 34
Opportunities and challenges in the wider adoption of liver and interconnected microphysiological systems
2017 · David J Hughes, Tomasz Kostrzewski, et al. · Experimental Biology and Medicine · 33
A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models
2022 · Dharaminder Singh, Sudhir P. Deosarkar, et al. · PLoS Biology · 26
PDF
Abstract LB-044: In vitro assessment of combination dosing regimens with in vivo like pharmacokinetic concentration profiles enabled by a microfluidic addition and removal device
2018 · Paul Golby, Edoardo Buffa, et al. · Cancer Research · 2
Assessment of inhaled medications using an in vitro human alveolar microphysiological system.
2022 · E Richardson, H Sze, et al. · European Respiratory Journal · 1
LP-45 Evaluating different modalities of drug-induced liver injury using a sensitive and selective human liver microphysiological system and clinical biomarkers
2022 · O. Novac, R. Silva, et al. · Toxicology Letters
Abstract 182: Bridging gaps in translational biology: Exploring pharmacokinetic/pharmacodynamic/efficacy relationships and combination treatments in 3D tumor models using a microphysiological system
2022 · Tudor Petreus, Tomasz Kostrzewski, et al. · Cancer Research
Development of novel alveolar and bronchial microphysiological systems for use in disease research and drug development.
2022 · Emily Richardson, Hailey Sze, et al.
Abstract 1931: Investigating the PK/PD/efficacy relationship of PI3K inhibitors in vitro , enabled by a microfluidic addition and removal device
2019 · Tomasz M. Kostrzewski, Dharaminder Singh, et al. · Cancer Research
Three-Dimensional Human Cell Culture Model for Studying Non-Alcoholic Fatty Liver Disease
2016 · T. Kostrzewski, T. Cornforth, et al. · Journal of Hepatology
Assessment of Drug Clearance, Metabolite Profile, and Drug Induced Toxicity in a Coculture of Human 3D Liver and Gut Microphysiological Systems: : Toward developing a perfused human liver‐gut interactome
2015 · U. Sarkar, S. Tannenbaum, et al. · The FASEB Journal
Systems pharmacology guided platform development for the integrated Microphysiological Systems
2015 · Jiajie Yu, Murat Cirit, et al. · The FASEB Journal
Works count: 26
Citation count: 1,983
H-index: 16
I10-index: 16
Year
Topic
Type