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Nikolaos Nikolaou
Observed names:
N. Nikolaou,
Nikolaou N,
Nikolaou, Nikolaos
Observed institutions:
Queen Elizabeth Hospital Birmingham,
Churchill Hospital,
National Institute for Health and Care Research,
University of Oxford,
NIHR Oxford Biomedical Research Centre,
Oxford Centre for Diabetes, Endocrinology and Metabolism,
University of Birmingham
show all 7
ORCID:
0000-0002-8789-8436
Observed ORCID:
0000-0002-8789-8436
OpenAlex ID:
A5101927643
Development of Hepatocellular Carcinoma in a Murine Model of Nonalcoholic Steatohepatitis Induced by Use of a High-Fat/Fructose Diet and Sedentary Lifestyle
2014
·
Joanna K. Dowman
, Laurence J. Hopkins
, et al.
·
American Journal Of Pathology
·
122
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
2019
·
Nikolaos Nikolaou
, Laura L. Gathercole
, et al.
·
Metabolism
·
87
PDF
Loss of 5α-Reductase Type 1 Accelerates the Development of Hepatic Steatosis but Protects Against Hepatocellular Carcinoma in Male Mice
2013
·
Joanna K. Dowman
, Laurence J. Hopkins
, et al.
·
Endocrinology
·
83
PDF
Modified release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia
2016
·
Christopher M. Jones
, Ashwini Mallappa
, et al.
·
The Journal of Clinical Endocrinology & Metabolism
·
75
Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man
2015
·
Jonathan M. Hazlehurst
, Andrei I. Oprescu
, et al.
·
The Journal of Clinical Endocrinology & Metabolism
·
72
PDF
5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes
2015
·
Maryam Nasiri
, Nikolaos Nikolaou
, et al.
·
Endocrinology
·
51
PDF
11β-HSD1 inhibition in men mitigates prednisolone-induced adverse effects in a proof-of-concept randomised double-blind placebo-controlled trial
2023
·
Nantia Othonos
, Riccardo Pofi
, et al.
·
Nature Communications
·
48
PDF
Modified-Release and Conventional Glucocorticoids and Diurnal Androgen Excretion in Congenital Adrenal Hyperplasia
2018
·
Jones CM
, Mallappa A
, et al.
·
Yearbook of pediatric endocrinology
·
41
Optimizing human hepatocyte models for metabolic phenotype and function: effects of treatment with dimethyl sulfoxide (DMSO)
2016
·
Nikolaos Nikolaou
, Charlotte J. Green
, et al.
·
Physiological Reports
·
35
PDF
The role of 5-reduction in physiology and metabolic disease: evidence from cellular, pre-clinical and human studies
2021
·
Nikolaos Nikolaou
, Leanne Hodson
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
26
The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1
2020
·
Lise Barnard
, Nikolaos Nikolaou
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
25
PDF
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells
2019
·
Nikolaos Nikolaou
, Laura L. Gathercole
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
24
Acute intermittent hypoxia drives hepatic de novo lipogenesis in humans and rodents
2022
·
Jonathan M. Hazlehurst
, Teegan Reina Lim
, et al.
·
Metabolism Open
·
19
PDF
Co-administration of 5α-reductase Inhibitors Worsens the Adverse Metabolic Effects of Prescribed Glucocorticoids
2020
·
Nantia Othonos
, Thomas Marjot
, et al.
·
The Journal of Clinical Endocrinology & Metabolism
·
14
PDF
Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo
2020
·
Nikolaos Nikolaou
, Anastasia Arvaniti
, et al.
·
Journal of Endocrinology
·
14
PDF
Differential activity and expression of human 5β-reductase (AKR1D1) splice variants
2021
·
Nathan Appanna
, Hylton Gibson
, et al.
·
Journal of Molecular Endocrinology
·
11
PDF
Development of optimised human iPSC-derived hepatocytes with improved liver function for in vitro metabolic disease modelling and toxicity studies
2024
·
Magdalena Łukasiak
, Gemma Gatti
, et al.
·
bioRxiv (Cold Spring Harbor Laboratory)
·
4
iPSC-derived hepatocytes accurately recapitulate population diversity in alpha-1-antitrypsin deficiency and offer a novel in vitro model for large-scale drug efficacy screening studies
2025
·
Carlos Gil
, Vanesa Papastavrou
, et al.
·
bioRxiv (Cold Spring Harbor Laboratory)
·
2
PDF
AKR1D1 knockdown identifies 7[alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) as a driver of metabolic dysfunction and hepatocellular cancer risk in patients with non-alcoholic fatty liver disease (NAFLD)
2022
·
Nikolaos Nikolaou
, Anastasia Arvaniti
, et al.
·
Endocrine Abstracts
·
2
Gender specific metabolic phenotype in the 5[beta]-reductase knockout mouse
2017
·
Laura Gathercole
, Petra Klusonova
, et al.
·
Endocrine Abstracts
·
2
7[alpha]-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA) is a novel AKR1D1 substrate driving metabolic dysfunction and hepatocellular cancer risk in patients with non-alcoholic fatty liver disease (NAFLD)
2022
·
Nikolaos Nikolaou
, Anastasia Arvaniti
, et al.
·
Endocrine Abstracts
·
1
AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease
2019
·
Nikolaos Nikolaou
, Laura L Gathercole
, et al.
·
Endocrine Abstracts
·
1
Optimising human hepatocyte models for metabolic phenotype: effects of treatment with DMSO
2016
·
Nikolaos Nikolaou
, Charlotte Green
, et al.
·
Endocrine Abstracts
·
1
PDF
Dual 5[alpha]-reductase inhibition causes hepatic lipid accumulation in man
2015
·
Jonathan Hazlehurst
, Andrei Oprescu
, et al.
·
Endocrine Abstracts
·
1
PDF
Regulation of lipogenesis in human hepatocytes by androgens, glucocorticoids, and 5[alpha]-reductase
2015
·
Nikolaos Nikolaou
, Maryam Nasiri
, et al.
·
Endocrine Abstracts
·
1
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Works count:
65
Citation count:
762
H-index:
14
I10-index:
16
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