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Dearg S. Brown

Observed names: D. S. BROWN, D. S. Brown, D.S. Brown, Dearg Brown
Observed institutions: AstraZeneca (United Kingdom), University of Leeds, University of Strathclyde, University of Cambridge, Imperial College London, The University of Texas at Austin
OpenAlex ID: A5102102382
Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
2014 · David Cook, Dearg Brown, et al. · Nature Reviews Drug Discovery · 1,347
Specific inhibition of epidermal growth factor receptor tyrosine kinase by 4-anilinoquinazolines
1996 · A. E. Wakeling, A. J. Barker, et al. · Breast Cancer Research and Treatment · 166
Substitution reactions of 2-benzenesulphonyl cyclic ethers with carbon nucleophiles
1989 · Dearg S. Brown, Maurizio Bruno, et al. · Tetrahedron · 109
Multi‐Step Application of Immobilized Reagents and Scavengers: A Total Synthesis of Epothilone C
2004 · R. Ian Storer, Toshiyasu Takemoto, et al. · Chemistry - A European Journal · 86
Chiral aluminium complexes as phospho-transfer catalysts
1999 · Julian P. Duxbury, Anthony Cawley, et al. · Tetrahedron Letters · 84
Substitution reactions of 2-phenylsulphonyl-piperidines and -pyrrolidines with carbon nucleophiles: Synthesis of the pyrrolidine alkaloids norruspoline and ruspolinone
1991 · Dearg S. Brown, Philippe Charreau, et al. · Tetrahedron · 80
a palladium catalysed cascade cyclisation-friedel-crafts alkylation approach to angularly fused ring systems
1995 · Dearg Brown, Konald Grigg, et al. · Tetrahedron Letters · 79
Strategies to improve in vivo toxicology outcomes for basic candidate drug molecules
2011 · Tim Luker, Lilian Alcaraz, et al. · Bioorganic & Medicinal Chemistry Letters · 59
Direct substitution of 2-benzenesulphonyl cyclic ethers using organozinc reagents
1988 · Dearg S. Brown, Steven V. Ley · Tetrahedron Letters · 59
Use of 2-phenylsulphonyl cyclic ethers in the preparation of tetrahydropyran and tetrahydrofuran acetals and in some glycosidation reactions.
1991 · Dearg S. Brown, Steven V. Ley, et al. · Tetrahedron · 56
Epidermal growth factor receptor tyrosine kinase: Structure-activity relationships and antitumour activity of novel quinazolines
1997 · K.H. Gibson, W Grundy, et al. · Bioorganic & Medicinal Chemistry Letters · 55
Preparation of cyclic ether acetals from 2-benzenesulphonylderivatives: a new mild glycosidation procedure
1988 · Dearg S. Brown, Steven V. Ley, et al. · Tetrahedron Letters · 50
Palladium catalysed cyclisation- intermolecular cyclopropanation versus cyclisation Friedel- Crafts alkylation with olefin insertion
1998 · Dearg Brown, Ronald Grigg, et al. · Tetrahedron · 39
Synthesis of the acyltetronic acid ionophore tetronasin (ICI M139603)
1998 · Steven V. Ley, Dearg S. Brown, et al. · Journal of the Chemical Society Perkin Transactions 1 · 32
Synthetic studies on furanoheliangolides. Stereocontrolled construction of the oxygen-bridged tricyclic framework
1992 · Dearg S. Brown, Leo A. Paquette · The Journal of Organic Chemistry · 32
Balancing hERG affinity and absorption in the discovery of AZD5672, an orally active CCR5 antagonist for the treatment of rheumatoid arthritis
2012 · John G. Cumming, Howard Tucker, et al. · Bioorganic & Medicinal Chemistry Letters · 29
A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis
2004 · Dearg S. Brown, Andrew J. Belfield, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Direct Substitution of 2-Benzenesulphonylpiperidines and -pyrrolidines by Carbon Nucleophiles: Synthesis of the Pyrrolidine Alkaloid Ruspolinone
1990 · Dearg S. Brown, Thomas Hansson, et al. · Synlett · 25
Direct Substitution of 2-Phenylsulphonylpyrrolidines, -piperidines, -tetrahydrofurans and -tetrahydropyrans by Alkyl Organometallic Reagents in Dichloromethane
1990 · Dearg S. Brown, Philippe Charreau, et al. · Synlett · 25
New .kappa.-receptor agonists based upon a 2-[(alkylamino)methyl]piperidine nucleus
1992 · David I. C. Scopes, Norman F. Hayes, et al. · Journal of Medicinal Chemistry · 22
Polymer-Supported N-Methylmorpholine N-Oxide as an Efficient and Readily Recyclable Co-oxidant in the TPAP Oxidation of Alcohols
2001 · Dearg S. Brown, William J. Kerr, et al. · Synlett · 17
Two new routes to the C19C26 tetrahydrofuran fragment of the acyl tetronic acid ionophore tetronasin (ICI M139603)
1994 · Geert-Jan Boons, Dearg S. Brown, et al. · Tetrahedron Letters · 17
Substitution Reactions of 2-Benzensulphonyl Cyclic Ethers with Silyl Enol Ethers Promoted by Aluminium Trichloride
1989 · Steven V. Ley, Dearg S. Brown, et al. · Heterocycles · 17
Merrifield, Alpha-MethoxyPhenyl (MAMP) resin; a new versatile solid support for the synthesis of secondary amides
1998 · Dearg S. Brown, John M. Revill, et al. · Tetrahedron Letters · 14
Stereoselective redox transformations of phosphorus heterocycles.
2003 · Mark J. Cain, Anthony Cawley, et al. · Inorganica Chimica Acta · 13
Works count: 55
Citation count: 2,612
H-index: 20
I10-index: 27
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