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Linus L. Shen
Observed names:
L L Shen,
L. L. SHEN,
L. L. Shen,
L.L. Shen,
Linus L Shen,
Linus Shen,
Linus. L. Shen,
Shen, L.L.
show all 8
Observed institutions:
University of North Carolina at Chapel Hill,
University of Kansas,
Abbott (United Kingdom),
Abbott (United States),
Metabolic Diseases Research Center,
The Ohio State University
show all 6
OpenAlex ID:
A5102116431
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: a cooperative drug-DNA binding model
1989
·
Linus L. Shen
, Lester A. Mitscher
, et al.
·
Biochemistry
·
415
Mechanism of inhibition of DNA gyrase by analogues of nalidixic acid: the target of the drugs is DNA.
1985
·
L L Shen
, A G Pernet
·
Proceedings of the National Academy of Sciences
·
369
Mechanism of quinolone inhibition of DNA gyrase
1989
·
L L Shen
, W E Kohlbrenner
, et al.
·
Journal of Biological Chemistry
·
216
The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors
2000
·
Qun Li
, Lester A. Mitscher
, et al.
·
Medicinal Research Reviews
·
211
Mechanism of inhibition of DNA gyrase by quinolone antibacterials: specificity and cooperativity of drug binding to DNA
1989
·
Linus L. Shen
, John Baranowski
, et al.
·
Biochemistry
·
180
Mass–length ratio of fibrin fibers from gel permeation and light scattering
1977
·
Marcus E. Carr
, Linus L. Shen
, et al.
·
Biopolymers
·
178
In Vitro Antibacterial Potency and Spectrum of ABT-492, a New Fluoroquinolone
2003
·
Angela M. Nilius
, Linus L. Shen
, et al.
·
Antimicrobial Agents and Chemotherapy
·
120
Effects of calcium ion and covalent crosslinking on formation and elasticity of fibrin gels
1975
·
L.L. Shen
, J. Hermans
, et al.
·
Thrombosis Research
·
106
Chiral DNA gyrase inhibitors. 2. Asymmetric synthesis and biological activity of the enantiomers of 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid (ofloxacin)
1987
·
Lester A. Mitscher
, Padam N. Sharma
, et al.
·
Journal of Medicinal Chemistry
·
103
Mechanism of differential activities of ofloxacin enantiomers
1996
·
I Morrissey
, K Hoshino
, et al.
·
Antimicrobial Agents and Chemotherapy
·
99
DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs
1992
·
L L Shen
, J Baranowski
, et al.
·
Antimicrobial Agents and Chemotherapy
·
82
Topoisomerase II Poisoning by ICRF-193
2001
·
Kuan-Chun Huang
, Hanlin Gao
, et al.
·
Journal of Biological Chemistry
·
81
Synthesis and Structure−Activity Relationships of 2-Pyridones: A Novel Series of Potent DNA Gyrase Inhibitors as Antibacterial Agents
1996
·
Qun Li
, Daniel T. W. Chu
, et al.
·
Journal of Medicinal Chemistry
·
76
Quinobenoxazines: A Class of Novel Antitumor Quinolones and Potent Mammalian DNA Topoisomerase II Catalytic Inhibitors
1994
·
Paskasari A. Permana
, Robert M. Snapka
, et al.
·
Biochemistry
·
72
Design, synthesis, and properties of (4S)-7-(4-amino-2-substituted-pyrrolidin-1-yl)quinolone-3-carboxylic acids
1988
·
Terry Rosen
, Daniel T. W. Chu
, et al.
·
Journal of Medicinal Chemistry
·
64
Synthesis and Antimicrobial Activity of 4H-4-Oxoquinolizine Derivatives: Consequences of Structural Modification at the C-8 Position
1999
·
Zhenkun Ma
, Daniel T. W. Chu
, et al.
·
Journal of Medicinal Chemistry
·
62
Kinetics of conformation change of sperm-whale myoglobin. I. Folding and unfolding of metmyoglobin following pH jump
1972
·
Linus L. Shen
, Jan Hermans
·
Biochemistry
·
58
Early events in the plasmin digestion of fibrinogen and fibrin. Effects of plasmin on fibrin polymerization.
1977
·
L L Shen
, R P McDonagh
, et al.
·
Journal of Biological Chemistry
·
54
Fibrin gel structure: Influence of calcium and covalent cross-linking on the elasticity
1974
·
Linus L. Shen
, Richard P. McDonagh
, et al.
·
Biochemical and Biophysical Research Communications
·
54
DNA Cleavage Activities of Staphylococcus aureus Gyrase and Topoisomerase IV Stimulated by Quinolones and 2-Pyridones
1999
·
Anne Y. C. Saiki
, Linus L. Shen
, et al.
·
Antimicrobial Agents and Chemotherapy
·
51
PDF
Molecular Mechanisms of DNA Gyrase Inhibition by Quinolone Antibacterials
1994
·
Linus L. Shen
·
Advances in pharmacology
·
45
Chloroquinoxaline sulfonamide (NSC 339004) is a topoisomerase IIalpha/beta poison.
2000
·
H Gao
, E F Yamasaki
, et al.
·
PubMed
·
44
Type II DNA Topoisomerases as Antibacterial Targets
1996
·
L. L. Shen
, D. T. W. Chu
·
Current Pharmaceutical Design
·
43
Asymmetric synthesis and properties of the enantiomers of the antibacterial agent 7-(3-aminopyrrolidin-1-yl)-1-(2,4-difluorophenyl)-1,4-dihydro-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride
1988
·
Terry Rosen
, Daniel T. W. Chu
, et al.
·
Journal of Medicinal Chemistry
·
43
DNA Sequence Specificity for Topoisomerase II Poisoning by the Quinoxaline Anticancer Drugs XK469 and CQS
2003
·
Hanlin Gao
, Edith F. Yamasaki
, et al.
·
Molecular Pharmacology
·
41
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Works count:
59
Citation count:
3,350
H-index:
32
I10-index:
40
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