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Hiroyuki Mizuguchi

Observed names: H. Mizuguchi, Mizuguchi, H., Mizuguchi, Hiroyuki, 博之 水口
ORCID: 0000-0002-2497-8033
Observed ORCID: 0000-0002-2497-8033
OpenAlex ID: A5102921416
Involvement of Protein Kinase Cδ/Extracellular Signal-regulated Kinase/Poly(ADP-ribose) Polymerase-1 (PARP-1) Signaling Pathway in Histamine-induced Up-regulation of Histamine H1 Receptor Gene Expression in HeLa Cells
2011 · Hiroyuki Mizuguchi, Takuma Terao, et al. · Journal of Biological Chemistry · 66
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Preseasonal prophylactic treatment with antihistamines suppresses nasal symptoms and expression of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis
2010 · Mizuguchi, H., Kitamura, Y., et al. · Methods and Findings in Experimental and Clinical Pharmacology · 52
Repeated Pre-treatment With Antihistamines Causes Transcriptional Up-regulations of Histamine H1 Receptor and Interleukin-4 Genes in Toluene-2,4-diisocyanate–Sensitized Rats
2008 · Hiroyuki Mizuguchi, Masaya Hatano, et al. · Journal of Pharmacological Sciences · 49
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Suppression of Histamine Signaling by Probiotic Lac-B: a Possible Mechanism of Its Anti-allergic Effect
2008 · Shrabanti Dev, Hiroyuki Mizuguchi, et al. · Journal of Pharmacological Sciences · 46
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Maackiain is a novel antiallergic compound that suppresses transcriptional upregulation of the histamine H1 receptor and interleukin‐4 genes
2015 · Hiroyuki Mizuguchi, Yuki Nariai, et al. · Pharmacology Research & Perspectives · 42
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Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between bosentan and ambrisentan
2020 · Shotaro Michinaga, Anna Inoue, et al. · Neuropharmacology · 41
Mast cell stabilization and antihistaminic potentials of Curculigo orchioides rhizomes
2009 · P. Venkatesh, Pulok K. Mukherjee, et al. · Journal of Ethnopharmacology · 41
Suplatast Tosilate Inhibits Histamine Signaling by Direct and Indirect Down-Regulation of Histamine H1 Receptor Gene Expression through Suppression of Histidine Decarboxylase and IL-4 Gene Transcriptions
2009 · Masum Shahriar, Hiroyuki Mizuguchi, et al. · The Journal of Immunology · 39
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Sho-seiryu-to Suppresses Histamine Signaling at the Transcriptional Level in TDI-Sensitized Nasal Allergy Model Rats
2009 · Asish Kumar Das, Hiroyuki Mizuguchi, et al. · Allergology International · 38
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Quercetin inhibits transcriptional up-regulation of histamine H1 receptor via suppressing protein kinase C-δ/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells
2013 · Masashi Hattori, Hiroyuki Mizuguchi, et al. · International Immunopharmacology · 33
Inverse Agonistic Activity of Antihistamines and Suppression of Histamine H1 Receptor Gene Expression
2011 · Hiroyuki Mizuguchi, Shohei Ono, et al. · Journal of Pharmacological Sciences · 32
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Angiopoietin‐1/Tie‐2 signal after focal traumatic brain injury is potentiated by BQ788, an ETB receptor antagonist, in the mouse cerebrum: Involvement in recovery of blood–brain barrier function
2020 · Shotaro Michinaga, Ayami Tanabe, et al. · Journal of Neurochemistry · 29
PMA-induced dissociation of Ku86 from the promoter causes transcriptional up-regulation of histamine H1 receptor
2012 · Hiroyuki Mizuguchi, Kohei Miyagi, et al. · Scientific Reports · 28
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Down-regulation of astrocytic sonic hedgehog by activation of endothelin ETB receptors: Involvement in traumatic brain injury-induced disruption of blood brain barrier in a mouse model
2021 · Shotaro Michinaga, Ayana Inoue, et al. · Neurochemistry International · 27
Disruption of Heat Shock Protein 90 (Hsp90)-Protein Kinase Cδ (PKCδ) Interaction by (−)-Maackiain Suppresses Histamine H1 Receptor Gene Transcription in HeLa Cells
2015 · Yuki Nariai, Hiroyuki Mizuguchi, et al. · Journal of Biological Chemistry · 26
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Deprivation of anticipated food under scheduled feeding induces c-Fos expression in the caudal part of the arcuate nucleus of hypothalamus through histamine H1 receptors in rats: Potential involvement of E3 subgroup of histaminergic neurons in tuberomammillary nucleus
2011 · Hayato Umehara, Hiroyuki Mizuguchi, et al. · Brain Research · 21
Effects of antihistamine on up-regulation of histamine H1 receptor mRNA in the nasal mucosa of patients with pollinosis induced by controlled cedar pollen challenge in an environmental exposure unit
2015 · Yoshiaki Kitamura, Hideyuki Nakagawa, et al. · Journal of Pharmacological Sciences · 20
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The isolation and synthesis of a novel benzofuran compound from Tephrosia purpurea, and the synthesis of several related derivatives, which suppress histamine H1 receptor gene expression
2015 · Manik Chandra Shill, Asish Kumar Das, et al. · Bioorganic & Medicinal Chemistry · 20
Identification of a histaminergic circuit in the caudal hypothalamus: An evidence for functional heterogeneity of histaminergic neurons
2012 · Hayato Umehara, Hiroyuki Mizuguchi, et al. · Neurochemistry International · 20
Usefulness of HeLa cells to evaluate inverse agonistic activity of antihistamines
2013 · Hiroyuki Mizuguchi, Shohei Ono, et al. · International Immunopharmacology · 18
Identification of epigallocatechin-3-O-gallate as an active constituent in tea extract that suppresses transcriptional up-regulations of the histamine H1 receptor and interleukin-4 genes
2008 · Chiyo Matsushita, Hiroyuki Mizuguchi, et al. · 18
Pharmacological Inhibition of Transient Receptor Potential Vanilloid 4 Reduces Vasogenic Edema after Traumatic Brain Injury in Mice
2021 · Shotaro Michinaga, Kazuya Onishi, et al. · Biological and Pharmaceutical Bulletin · 17
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Elucidation of Inverse Agonist Activity of Bilastine
2020 · Hiroyuki Mizuguchi, Tomoharu Wakugawa, et al. · Pharmaceutics · 15
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Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis
2018 · Rezwanul Islam, Hiroyuki Mizuguchi, et al. · The Journal of Medical Investigation · 15
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Suplatast tosilate alleviates nasal symptoms through the suppression of nuclear factor of activated T-cells-mediated IL-9 gene expression in toluene-2,4-diisocyanate-sensitized rats
2016 · Hiroyuki Mizuguchi, Naoki Orimoto, et al. · Journal of Pharmacological Sciences · 14
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Works count: 97
Citation count: 925
H-index: 19
I10-index: 31
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