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Jenny Roy

Impact of estradiol structural modifications (18-methyl and/or 17-hydroxy inversion of configuration) on the in vitro and in vivo estrogenic activity
2011 · Diana Ayan, Jenny Roy, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 58
In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure – activity relationships
2008 · Aurelian Gulea, Donald Poirier, et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 53
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A New Nonestrogenic Steroidal Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type I Blocks the Estrogen-Dependent Breast Cancer Tumor Growth Induced by Estrone
2012 · Diana Ayan, René Maltais, et al. · Molecular Cancer Therapeutics · 44
2β-(N-Substituted Piperazino)-5α-Androstane-3α,17β-Diols: Parallel Solid-Phase Synthesis and Antiproliferative Activity on Human Leukemia HL-60 Cells
2007 · Jenny Roy, Patrick DeRoy, et al. · Journal of Combinatorial Chemistry · 40
Copper(II) and uranyl(II) complexes with acylthiosemicarbazide: Synthesis, characterization, antibacterial activity and effects on the growth of promyelocytic leukemia cells HL-60
2009 · Madalina Veronica Angelusiu, Gabriela Laura Almajan, et al. · European Journal of Medicinal Chemistry · 39
Comparison of the effects of EM‐652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW‐5638 and raloxifene on the growth of human ZR‐75‐1 breast tumors in nude mice
2002 · Matthieu Gutman, Steeve Couillard, et al. · International Journal of Cancer · 37
Targeting Cytochrome P450 (CYP) 1B1 Enzyme with Four Series of A-Ring Substituted Estrane Derivatives: Design, Synthesis, Inhibitory Activity, and Selectivity
2018 · Raphaël Dutour, Jenny Roy, et al. · Journal of Medicinal Chemistry · 35
Design of a Mestranol 2‐N‐Piperazino‐Substituted Derivative Showing Potent and Selective in vitro and in vivo Activities in MCF‐7 Breast Cancer Models
2017 · Martin Perreault, René Maltais, et al. · ChemMedChem · 30
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Turning a Quinoline-based Steroidal Anticancer Agent into Fluorescent Dye for its Tracking by Cell Imaging
2021 · René Maltais, Jenny Roy, et al. · ACS Medicinal Chemistry Letters · 29
A novel aminosteroid of the 5α-androstane-3α,17β-diol family induces cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells
2010 · Hajer Jegham, Jenny Roy, et al. · Investigational New Drugs · 28
Chemical synthesis, NMR analysis and evaluation on a cancer xenograft model (HL-60) of the aminosteroid derivative RM-133
2014 · René Maltais, Audrey Delhomme, et al. · Steroids · 27
Chemical synthesis of 2β-amino-5α-androstane-3α,17β-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells
2008 · Dominic Thibeault, Jenny Roy, et al. · Bioorganic & Medicinal Chemistry · 27
Libraries of 2β-(N-substituted piperazino)-5α-androstane-3α, 17β-diols: chemical synthesis and cytotoxic effects on human leukemia HL-60 cells and on normal lymphocytes
2010 · Jenny Roy, René Maltais, et al. · Molecular Diversity · 26
A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models
2021 · Donald Poirier, Jenny Roy, et al. · Cancers · 22
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Identification of steroidal derivatives inhibiting the transformations of allopregnanolone and estradiol by 17β-hydroxysteroid dehydrogenase type 10
2018 · Sophie Boutin, Jenny Roy, et al. · Bioorganic & Medicinal Chemistry Letters · 21
The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers
2015 · Lucie Carolle Kenmogne, Diana Ayan, et al. · PLoS ONE · 21
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Inhibition of dehydroepiandosterone sulfate action in androgen-sensitive tissues by EM-1913, an inhibitor of steroid sulfatase
2013 · Jenny Roy, Julie Lefebvre, et al. · Molecular and Cellular Endocrinology · 20
Synthesis of 17β-hydroxysteroid dehydrogenase type 10 steroidal inhibitors: Selectivity, metabolic stability and enhanced potency
2020 · Sophie Boutin, René Maltais, et al. · European Journal of Medicinal Chemistry · 19
Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model
2018 · Martin Perreault, René Maltais, et al. · Investigational New Drugs · 19
Structure-Based Design and Synthesis of New Estrane–Pyridine Derivatives as Cytochrome P450 (CYP) 1B1 Inhibitors
2017 · Raphaël Dutour, Francisco Cortés-Benítez, et al. · ACS Medicinal Chemistry Letters · 19
A Novel Pure SERM Achieves Complete Regression of the Majority of Human Breast Cancer Tumors in Nude Mice
2003 · Jenny Roy, Steeve Couillard, et al. · Breast Cancer Research and Treatment · 19
Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments
2017 · René Maltais, Alexandre Trottier, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 18
Design, chemical synthesis and biological evaluation of 3-spiromorpholinone/3-spirocarbamate androsterone derivatives as inhibitors of 17β-hydroxysteroid dehydrogenase type 3
2015 · Guy Bertrand Djigoué, Lucie Carolle Kenmogne, et al. · Bioorganic & Medicinal Chemistry · 18
An irreversible inhibitor of 17β-hydroxysteroid dehydrogenase type 1 inhibits estradiol synthesis in human endometriosis lesions and induces regression of the non-human primate endometriosis
2022 · Donald Poirier, Atunga Nyachieo, et al. · The Journal of Steroid Biochemistry and Molecular Biology · 17
Biological evaluation of a new family of aminosteroids that display a selective toxicity for various malignant cell lines
2012 · Hajer Jegham, René Maltais, et al. · Anti-Cancer Drugs · 17
Works count: 78
Citation count: 987
H-index: 19
I10-index: 41
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