Author

Mark E. Petersen

Observed names: M. Petersen, M.E. Petersen, Mark Petersen

Institution: Zymeworks (Canada)

Observed institutions: University of Utah, Zymeworks (Canada), Bureau international des poids et mesures

ORCID: 0000-0003-2629-1363

Observed ORCID: 0000-0003-2629-1363

OpenAlex ID: A5103028352

A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis

2016 · Michael T. Jacobsen, Mark E. Petersen, et al. · Journal of the American Chemical Society · 95

Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates

2024 · Mark E. Petersen, Michael G. Brant, et al. · Molecular Cancer Therapeutics · 30

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Synthesis of tumor necrosis factor α for use as a mirror-image phage display target

2016 · Mark E. Petersen, Michael T. Jacobsen, et al. · Organic & Biomolecular Chemistry · 26

Chemical synthesis of Shiga toxin subunit B using a next-generation traceless “helping hand” solubilizing tag

2019 · James M. Fulcher, Mark E. Petersen, et al. · Organic & Biomolecular Chemistry · 23

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Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal

2018 · Adam M. Spivak, Racheal A. Nell, et al. · Antimicrobial Agents and Chemotherapy · 23

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Comparison of transcriptional response to phorbol ester, bryostatin 1, and bryostatin analogs in LNCaP and U937 cancer cell lines provides insight into their differential mechanism of action

2012 · N. Kedei, A. Telek, et al. · Biochemical Pharmacology · 21

Synthesis of hydrophobic insulin-based peptides using a helping hand strategy

2018 · Maria M. Disotuar, Mark E. Petersen, et al. · Organic & Biomolecular Chemistry · 20

Generation and structure-activity relationships of novel imidazo-thienopyridine based TLR7 agonists: application as payloads for immunostimulatory antibody drug-conjugates

2023 · Michael G. Brant, Graham A.E. Garnett, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Biological activity of the bryostatin analog Merle 23 on mouse epidermal cells and mouse skin

2016 · Jessica S. Kelsey, Christophe Cataisson, et al. · Molecular Carcinogenesis · 10

Abstract 2658: ZW251, a novel glypican-3-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload

2023 · Laurence Madera, Andrea Hernández Rojas, et al. · Cancer Research · 6

Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cδ Provides an Integrated Measure of Its Modulation in Response to Ligands

2014 · Noemi Kedei, Jin-Qiu Chen, et al. · Journal of Medicinal Chemistry · 6

Structure–Activity Relationships of Bis-Intercalating Peptides and Their Application as Antibody–Drug Conjugate Payloads

2023 · Mark E. Petersen, Michael G. Brant, et al. · Journal of Medicinal Chemistry · 5

Replacement of the bryostatin A- and B-pyran rings with phenyl rings leads to loss of high affinity binding with PKC

2016 · Mark E. Petersen, Noemi Kedei, et al. · Tetrahedron Letters · 4

Abstract 1533: ZW220, a novel NaPi2b-targeting antibody drug conjugate bearing a topoisomerase 1 inhibitor payload

2023 · Andrea Hernandez Rojas, Jodi Wong, et al. · Cancer Research · 3

Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues

2018 · Thomas J. Cummins, Noemi Kedei, et al. · ChemBioChem · 3

Systematic Evaluation of Maleimide Spacer Impact on Drug-Linker Deconjugation in Antibody-Drug Conjugates Ex Vivo and In Vivo

2026 · Andrea Hernández Rojas, Jodi Wong, et al. · Bioconjugate Chemistry · 1

Abstract 2874: ZW327, a novel Ly6E-targeting antibody-drug conjugate bearing a topoisomerase 1 inhibitor payload

2025 · Dunja Urosev, Saki Konomura, et al. · Cancer Research · 1

6 Oral: ZW220, a NaPi2b-directed topoisomerase I inhibitor Antibody-Drug Conjugate, demonstrates compelling preclinical activity in NSCLC, ovarian and uterine cancer models, with a favorable toxicology profile in non-human primates

2024 · A. Hernandez, D. Urosev, et al. · European Journal of Cancer · 1

177 (PB165): ZW251, a novel glypican-3-targeting antibody-drug conjugate bearing a topoisomerase I inhibitor payload demonstrates compelling preclinical activity in hepatocellular carcinoma models

2024 · L. Madera, A. Wu, et al. · European Journal of Cancer · 1

Abstract 1862: ZW191 - a FRα-targeting antibody drug conjugate with strong preclinical activity across multiple FRα-expressing indications

2024 · Sam Lawn, Andrea Hernandez Rojas, et al. · Cancer Research · 1

Supplementary Table S2 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates