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Yong Chu
Observed name:
Chu, Yong
Institutions:
Shanghai Medical College of Fudan University,
Fudan University
Observed institutions:
Shanghai Medical College of Fudan University,
Chinese Academy of Sciences,
Fudan University,
Shanghai Institute of Materia Medica,
State Key Laboratory of Drug Research
ORCID:
0000-0002-1770-9767
Observed ORCID:
0000-0002-1770-9767
OpenAlex ID:
A5103040367
Design, synthesis and biological evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β)
2012
·
Peng Zhang
, Hai-Rong Hu
, et al.
·
European Journal of Medicinal Chemistry
·
48
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor
2018
·
Yali Li
, Taomin Huang
, et al.
·
European Journal of Medicinal Chemistry
·
31
Novel benzothiazinones (BTOs) as allosteric modulator or substrate competitive inhibitor of glycogen synthase kinase 3β (GSK-3β) with cellular activity of promoting glucose uptake
2014
·
Peng Zhang
, Shufen Li
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
30
Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice
2018
·
Mingguang Mo
, Jintong Yang
, et al.
·
Journal of Medicinal Chemistry
·
27
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia
2021
·
Peng Zhang
, Zhihui Min
, et al.
·
Journal of Medicinal Chemistry
·
20
An efficient one-pot procedure for the synthesis of 1,5-benzothiazepinones catalyzed by tetrabutylammonium fluoride (TBAF)
2016
·
Peng Zhang
, Deyong Ye
, et al.
·
Tetrahedron Letters
·
20
Synthetic Studies ond-Biotin, Part 6:An Expeditious and Enantiocontrolled Approach to the Total Synthesis ofd-Biotin via a Polymer-Supported Chiral Oxazaborolidine-Catalyzed Reduction ofmeso-Cyclic Imide Strategy
2003
·
Fen-Er Chen
, Jian-Li Yuan
, et al.
·
Synthesis
·
20
Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors
2015
·
Ya-li Li
, Xiang-yu Qi
, et al.
·
Bioorganic & Medicinal Chemistry
·
19
First total synthesis of (+)-Carainterol A
2010
·
Kaiqing Ma
, Chunbo Zhang
, et al.
·
Tetrahedron Letters
·
19
Identification of novel scaffold of benzothiazepinones as non-ATP competitive glycogen synthase kinase-3β inhibitors through virtual screening
2012
·
Peng Zhang
, Hai-Rong Hu
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
18
Discovery and anti-inflammatory evaluation of benzothiazepinones (BTZs) as novel non-ATP competitive inhibitors of glycogen synthase kinase-3β (GSK-3β)
2018
·
Yang Gao
, Peng Zhang
, et al.
·
Bioorganic & Medicinal Chemistry
·
17
Design, synthesis and identification of N, N-dibenzylcinnamamide (DBC) derivatives as novel ligands for α-synuclein fibrils by SPR evaluation system
2020
·
Yan-Fei Chen
, Jiang Bian
, et al.
·
Bioorganic & Medicinal Chemistry
·
16
UK5099 Inhibits the NLRP3 Inflammasome Independently of its Long‐Established Target Mitochondrial Pyruvate Carrier
2024
·
Linyu Ran
, Miao Chen
, et al.
·
Advanced Science
·
15
PDF
Discovery of styrylaniline derivatives as novel alpha-synuclein aggregates ligands
2021
·
Jiang Bian
, Yi-Qi Liu
, et al.
·
European Journal of Medicinal Chemistry
·
15
Small-molecule GLP-1 secretagogs: challenges and recent advances
2020
·
Jie He
, Yong Chu
·
Drug Discovery Today
·
13
The discovery of novel benzothiazinones as highly selective non-ATP competitive glycogen synthase kinase 3β inhibitors for the treatment of ovarian cancer
2017
·
Yang Gao
, De-Yong Ye
, et al.
·
European Journal of Medicinal Chemistry
·
12
Development, Validation, and Application of a Novel Method for Mammalian Sphingomyelin Synthase Activity Measurement
2012
·
Xiaodong Deng
, Hong Sun
, et al.
·
Analytical Letters
·
9
YC‐4‐3, a Novel Glycogen Synthase Kinase 3β Inhibitor, Alleviates the Endoplasmic Reticulum Stress of Macrophages in Primary Immune Thrombocytopenia
2025
·
Pengcheng Xu
, Lili Ji
, et al.
·
Advanced Science
·
6
Discovery of Phenylpyrazole Derivatives as a New Class of Selective Inhibitors of MCL‑1 with Antitumor Activity
2024
·
Qineng Gong
, Chunpu Li
, et al.
·
ACS Omega
·
5
Novel 4-triazole phenyl amide (4-TPA) molecules: Potent promoters of α-synuclein fibril disassembly
2024
·
Chenyang Qiu
, Ruonan Wei
, et al.
·
European Journal of Medicinal Chemistry
·
4
Studies on Constructing of the Key Intermediate of Eudesmane Sesquiterpenoid Analogues via Diels-Alder Reaction
2012
·
Yu Zhang
, Penghui Wang
, et al.
·
Chinese Journal of Organic Chemistry
·
4
PDF
Discovery of imidazo[1,2-b]pyridazine derivatives as potent TRK inhibitors for overcoming multiple resistant mutants
2025
·
Yunsheng Xu
, Wei Zhao
, et al.
·
Bioorganic Chemistry
·
3
A Practical Procedure for the Synthesis of 3-((e)-5-(2,3,4,5-tetramethoxy-6-methylphenyl)-3methylpent-3-enyl)-2,2-dimethyloxirane
2004
·
Yong Chu
, Yunyan Kuang
, et al.
·
Organic Preparations and Procedures International
·
2
Scaffold hopping for discovery of N, N-dibenzylcinnamamide (DBCA) derivatives as novel allosteric GSK-3β inhibitors: Design, synthesis and anti-inflammatory evaluation
2024
·
Xinyi Zhang
, Weiwei Zhao
, et al.
·
Results in Chemistry
·
1
2-(Furan-2-yl)-5-(2-nitrobenzyl)-2,3-dihydro-1,5-benzothiazepin-4(5H)-one
2010
·
Zhao-Hui Huang
, Yong Chu
, et al.
·
Acta Crystallographica Section E Structure Reports Online
·
1
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Works count:
34
Citation count:
373
H-index:
14
I10-index:
16
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