Author

Lai‐Ming Ching

Observed names: L M Ching, L. M. Ching, L.-M Ching, L.-M. Ching, L.M. Ching, Lai-Ming Ching

Observed institutions: Tulane University, European Organisation for Research and Treatment of Cancer, Centre National de la Recherche Scientifique, Uniformed Services University of the Health Sciences, University of Auckland, Cancer Society of New Zealand, Centre de Biophysique Moléculaire, Maurice Wilkins Centre

ORCID: 0000-0002-9745-2868

Observed ORCID: 0000-0002-9745-2868

OpenAlex ID: A5103189660

Non-Invasive Biomarkers for Early Detection of Breast Cancer

2020 · Jiawei Li, Xin Guan, et al. · Cancers · 261

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The chemotherapeutic agent DMXAA potently and specifically activates the TBK1–IRF-3 signaling axis

2007 · Zachary J. Roberts, Nadege Goutagny, et al. · The Journal of Experimental Medicine · 169

Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8+ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma

2005 · Arminder S. Jassar, Eiji Suzuki, et al. · Cancer Research · 148

Induction of tumour necrosis factor-? by single and repeated doses of the antitumour agent 5,6-dimethylxanthenone-4-acetic acid

1995 · Martin Philpott, Bruce C. Baguley, et al. · Cancer Chemotherapy and Pharmacology · 108

Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.

1991 · L L Thomsen, L M Ching, et al. · PubMed · 104

Evidence for the production of nitric oxide by activated macrophages treated with the antitumor agents flavone-8-acetic acid and xanthenone-4-acetic acid.

1990 · L L Thomsen, L M Ching, et al. · PubMed · 88

Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512)

1987 · Lai-Ming Ching, Bruce C. Baguley · European Journal of Cancer and Clinical Oncology · 83

Mechanisms of tumor vascular shutdown induced by 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA): Increased tumor vascular permeability

2005 · Liangli Zhao, Lai‐Ming Ching, et al. · International Journal of Cancer · 73

DMXAA: An antivascular agent with multiple host responses

2002 · Bruce C Baguley, Lai-Ming Ching · International Journal of Radiation Oncology*Biology*Physics · 64

Cell line selectivity and DNA breakage properties of the antitumour agent N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide: role of DNA topoisomerase II

1988 · Erasmus Schneider, Sandra J. Darkin, et al. · European Journal of Cancer and Clinical Oncology · 64

Thalidomide Pharmacokinetics and Metabolite Formation in Mice, Rabbits, and Multiple Myeloma Patients

2004 · Francisco Chung, Jun Lu, et al. · Clinical Cancer Research · 62

Immunomodulatory Actions of Xanthenone Anticancer Agents

1997 · Bruce C. Baguley, Lai-Ming Ching · BioDrugs · 60

Interferon-inducible protein 10 induction and inhibition of angiogenesis in vivo by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA).

2001 · Z Cao, B C Baguley, et al. · PubMed · 53

The role of autocrine TGFβ1 in endothelial cell activation induced by phagocytosis of necrotic trophoblasts: a possible role in the pathogenesis of pre‐eclampsia

2010 · Qi Chen, Limei Chen, et al. · The Journal of Pathology · 52

Metabolism of Thalidomide in Liver Microsomes of Mice, Rabbits, and Humans

2004 · Jun Lu, Nuala Helsby, et al. · Journal of Pharmacology and Experimental Therapeutics · 51

Vascular attack by 5,6-dimethylxanthenone-4-acetic acid combined with B7.1 (CD80)-mediated immunotherapy overcomes immune resistance and leads to the eradication of large tumors and multiple tumor foci.

2001 · J R Kanwar, R K Kanwar, et al. · PubMed · 51

Neutrophil Influx and Chemokine Production during the Early Phases of the Antitumor Response to the Vascular Disrupting Agent DMXAA (ASA404)

2009 · Liang-Chuan S. Wang, Lotte Thomsen, et al. · Neoplasia · 48

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Activation of LPS-inducible genes by the antitumor agent 5,6-dimethylxanthenone-4-acetic acid in primary murine macrophages. Dissection of signaling pathways leading to gene induction and tyrosine phosphorylation.

1994 · P Y Perera, S A Barber, et al. · The Journal of Immunology · 48

Enhancement of in vitro cytotoxicity of mouse peritoneal exudate cells by flavone acetic acid (NSC 347512)

1988 · Lai-Ming Ching, Bruce C. Baguley · European Journal of Cancer and Clinical Oncology · 47

The Vascular Disrupting Agent, DMXAA, Directly Activates Dendritic Cells through a MyD88-Independent Mechanism and Generates Antitumor Cytotoxic T Lymphocytes

2007 · Africa Wallace, David F. LaRosa, et al. · Cancer Research · 44

The antitumour agent 5,6-dimethylxanthenone-4-acetic acid acts in vitro on human mononuclear cells as a co-stimulator with other inducers of tumour necrosis factor

2001 · M. Philpott, L.-M. Ching, et al. · European Journal of Cancer · 43

Discovery and evaluation of inhibitors to the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1): Probing the active site-inhibitor interactions

2016 · Petr Tomek, Brian D. Palmer, et al. · European Journal of Medicinal Chemistry · 41

IFN- β -Dependent Inhibition of Tumor Growth by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA)

2008 · Zachary J. Roberts, Lai-Ming Ching, et al. · Journal of Interferon & Cytokine Research · 34

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1)

2013 · Sai-Parng S. Fung, Haiyan Wang, et al. · Bioorganic & Medicinal Chemistry · 29

Connexin hemichannel induced vascular leak suggests a new paradigm for cancer therapy

2014 · Jie Zhang, Simon J. O'Carroll, et al. · FEBS Letters · 25

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Works count: 85

Citation count: 2,580

H-index: 25

I10-index: 62