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Chunlan Pu

Discovery of a PROTAC targeting ALK with in vivo activity
2021 · Guoyi Yan, Xinxin Zhong, et al. · European Journal of Medicinal Chemistry · 59
Assessing the performance of docking scoring function, FEP, MM-GBSA, and QM/MM-GBSA approaches on a series of PLK1 inhibitors
2017 · Chunlan Pu, Guoyi Yan, et al. · MedChemComm · 56
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Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer
2022 · Chunlan Pu, Yu Tong, et al. · European Journal of Medicinal Chemistry · 55
Development of PROTAC degrader probe of CDK4/6 based on DCAF16
2023 · Yuanyuan Liu, Chunlan Pu, et al. · Bioorganic Chemistry · 47
Synthesis and biological evaluation of novel 2,3-dihydrochromeno[3,4-d]imidazol-4(1H)-one derivatives as potent anticancer cell proliferation and migration agents
2016 · Xuan Han, Jiang Luo, et al. · European Journal of Medicinal Chemistry · 38
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Anti-fibrotic effect of extracellular vesicles derived from tea leaves in hepatic stellate cells and liver fibrosis mice
2022 · Qianyuan Gong, Zhaoyu Zeng, et al. · Frontiers in Nutrition · 33
Current strategies for improving limitations of proteolysis targeting chimeras
2022 · Chunlan Pu, Shirui Wang, et al. · Chinese Chemical Letters · 32
Discovery of the GSH responsive “Y-PROTACs” targeting ALK and CDK4/6 as a potential treatment for cancer
2023 · Shirui Wang, Dan Luo, et al. · European Journal of Medicinal Chemistry · 31
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Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation
2024 · Shirui Wang, Zhanzhan Feng, et al. · Journal of Medicinal Chemistry · 30
Remodeling the gut ecosystem and its mechanism: Natural products in the treatment of ulcerative colitis via regulating gut microbiota and metabolites
2026 · Chuxi Zhang, Huacui Li, et al. · International Immunopharmacology · 29
Oral administration of tea-derived exosome-like nanoparticles protects epithelial and immune barrier of intestine from psychological stress
2024 · Qianyuan Gong, Yueshan Sun, et al. · Heliyon · 28
Recent advances in dual PROTACs degrader strategies for disease treatment
2024 · Jianyu Liu, Yanzhuo Liu, et al. · European Journal of Medicinal Chemistry · 25
Synthesis and biological evaluation of a tumor-selective degrader of PARP1
2022 · Chunlan Pu, Shirui Wang, et al. · Bioorganic & Medicinal Chemistry · 25
Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold
2021 · Huifang Shan, Xinyu Ma, et al. · European Journal of Medicinal Chemistry · 25
Discovery of 4-phenyl-2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as potent and orally active PI3K/mTOR dual inhibitors
2019 · Guoyi Yan, Chunlan Pu, et al. · European Journal of Medicinal Chemistry · 18
Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1
2024 · Dan Luo, Ronghua Luo, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
2017 · Chunlan Pu, Rong-Hua Luo, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy
2024 · Hongjia Zhang, Yan Zhang, et al. · Journal of Medicinal Chemistry · 15
Targeting Cysteine Located Outside the Active Site: An Effective Strategy for Covalent ALKi Design
2021 · Guoyi Yan, Xinxin Zhong, et al. · Journal of Medicinal Chemistry · 14
Synthesis and biological evaluation of a novel c-Myc inhibitor against colorectal cancer via blocking c-Myc/Max heterodimerization and disturbing its DNA binding
2022 · Qing Huang, Chunlan Pu, et al. · European Journal of Medicinal Chemistry · 10
Enhancing therapeutic efficacy in homologous recombination-proficient pancreatic cancer via the combination of PARP1-PROTAC and a BRD4 inhibitor
2024 · Chunlan Pu, Yuanyuan Liu, et al. · Bioorganic & Medicinal Chemistry · 8
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Lead optimization to improve the antiviral potency of 2-aminobenzamide derivatives targeting HIV-1 Vif-A3G axis
2021 · Xinxin Zhong, Ronghua Luo, et al. · European Journal of Medicinal Chemistry · 8
Identification of hit compounds for squalene synthase: Three‐dimensional quantitative structure‐activity relationship pharmacophore modeling, virtual screening, molecular docking, binding free energy calculation, and molecular dynamic simulation
2017 · M. Hou, G. Yan, et al. · Journal of Chemometrics · 8
Synthesis and biological evaluation of 3-(1,3,4-oxadiazol-2-yl)-1,8-naphthyridin-4(1 H )-ones as cisplatin sensitizers
2018 · Xueyan Hou, Hao Luo, et al. · MedChemComm · 7
Pharmacophore‐based virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation for the discovery of novel BRD 4 inhibitors
2017 · Guoyi Yan, Manzhou Hou, et al. · Chemical Biology & Drug Design · 7
Works count: 38
Citation count: 667
H-index: 16
I10-index: 20
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