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James D. Winkler

Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
2015 · Jing Lu, Yimin Qian, et al. · Chemistry & Biology · 1,160
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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
2016 · Kanak Raina, Jing Lu, et al. · Proceedings of the National Academy of Sciences · 872
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The codependence of angiogenesis and chronic inflammation
1997 · Jeffrey R. Jackson, Michael P. Seed, et al. · The FASEB Journal · 693
Targeted protein degradation by PROTACs
2017 · Taavi K. Neklesa, James D. Winkler, et al. · Pharmacology & Therapeutics · 611
Biological Characterization of ARRY-142886 (AZD6244), a Potent, Highly Selective Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor
2007 · Tammie C. Yeh, Vivienne Marsh, et al. · Clinical Cancer Research · 593
Mammalian Chk2 is a downstream effector of the ATM-dependent DNA damage checkpoint pathway
1999 · Priya Chaturvedi, Wai K Eng, et al. · Oncogene · 430
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
2003 · Erding Hu, Edward Dul, et al. · Journal of Pharmacology and Experimental Therapeutics · 353
Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor
2000 · Erding Hu, Zunxuan Chen, et al. · Journal of Biological Chemistry · 309
Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity
2000 · Bin-Bing S. Zhou, Priya Chaturvedi, et al. · Journal of Biological Chemistry · 280
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Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1
2017 · Andrew P. Crew, Kanak Raina, et al. · Journal of Medicinal Chemistry · 260
Control of arachidonate levels within inflammatory cells
1996 · Floyd H. Chilton, Alfred N. Fonteh, et al. · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · 242
Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7 Inhibit Apoptosis and Maintain Cell Functionality
2000 · Dennis Lee, Scott A. Long, et al. · Journal of Biological Chemistry · 237
An indolocarbazole inhibitor of human checkpoint kinase (Chk1) abrogates cell cycle arrest caused by DNA damage.
2000 · J R Jackson, A Gilmartin, et al. · PubMed · 229
4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
2005 · Lara S. Kallander, Qing Lu, et al. · Journal of Medicinal Chemistry · 191
Pharmacological Effects of SB 220025, a Selective Inhibitor of P38 Mitogen-Activated Protein Kinase, in Angiogenesis and Chronic Inflammatory Disease Models
1998 · Jeffrey R. Jackson, Brian Bolognese, et al. · Journal of Pharmacology and Experimental Therapeutics · 175
Clinical experience of MEK inhibitors in cancer therapy
2006 · Ding Wang, Scott A. Boerner, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 174
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Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7
2001 · Dennis Lee, Scott A. Long, et al. · Journal of Medicinal Chemistry · 168
Visualizing evolution in real time to determine the molecular mechanisms of n-butanol tolerance in Escherichia coli
2012 · Luis H. Reyes, Maria P. Almario, et al. · Metabolic Engineering · 113
Recent advances in the evolutionary engineering of industrial biocatalysts
2014 · James D. Winkler, Katy C. Kao · Genomics · 106
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Bacterial Recombineering: Genome Engineering via Phage-Based Homologous Recombination
2015 · Gur Pines, Emily F. Freed, et al. · ACS Synthetic Biology · 102
Relationship between Arachidonate−Phospholipid Remodeling and Apoptosis
1996 · Marc E. Surette, James D. Winkler, et al. · Biochemistry · 97
The signal transduction system of the leukotriene D4 receptor
1989 · Stanley T. Crooke, Mike Mattern, et al. · Trends in Pharmacological Sciences · 93
Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells
2002 · Zunxuan Chen, Steven Clark, et al. · Cancer Letters · 89
Constitutive expression of angiopoietin-1 and -2 and modulation of their expression by inflammatory cytokines in rheumatoid arthritis synovial fibroblasts.
2002 · Boyd B Scott, Paola F Zaratin, et al. · PubMed · 85
Cytosolic 85-kDa Phospholipase A2-mediated Release of Arachidonic Acid Is Critical for Proliferation of Vascular Smooth Muscle Cells
1997 · Karen M. Anderson, Amy Roshak, et al. · Journal of Biological Chemistry · 78
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Works count: 113
Citation count: 9,078
H-index: 39
I10-index: 65
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