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Jacques Lacroix

Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site
2010 · Sébastien Fortin, Jacques Lacroix, et al. · Biological Procedures Online · 79
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Antimitotic Antitumor Agents: Synthesis, Structure−Activity Relationships, and Biological Characterization of N-Aryl-N‘-(2-chloroethyl)ureas as New Selective Alkylating Agents
2001 · Emmanuelle Mounetou, Jean Legault, et al. · Journal of Medicinal Chemistry · 73
Nanoerythrosome, a new derivative of erythrocyte ghost: preparation and antineoplastic potential as drug carrier for daunorubicin.
1994 · A Lejeune, M Moorjani, et al. · PubMed · 69
Design, Synthesis, Biological Evaluation, and Structure–Activity Relationships of Substituted Phenyl 4-(2-Oxoimidazolidin-1-yl)benzenesulfonates as New Tubulin Inhibitors Mimicking Combretastatin A-4
2011 · Sébastien Fortin, Lianhu Wei, et al. · Journal of Medicinal Chemistry · 66
Microtubule disruption induced in vivo by alkylation of beta-tubulin by 1-aryl-3-(2-chloroethyl)ureas, a novel class of soft alkylating agents.
2000 · J Legault, J F Gaulin, et al. · PubMed · 60
Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities
2008 · Mounir Andaloussi, Emmanuel Moreau, et al. · European Journal of Medicinal Chemistry · 56
Antiangiogenic and Antitumoral Activity of Phenyl-3-(2-Chloroethyl)Ureas
2004 · Éric Petitclerc, Réna G. Deschesnes, et al. · Cancer Research · 52
Synthesis and growth inhibition activity of fluorinated derivatives of tamoxifen
2013 · Bianca Malo-Forest, Grégory Landelle, et al. · Bioorganic & Medicinal Chemistry Letters · 46
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships
2011 · Sébastien Fortin, Lianhu Wei, et al. · European Journal of Medicinal Chemistry · 39
A New Generation of N-Aryl-N‘-(1-alkyl-2-chloroethyl)ureas as Microtubule Disrupters: Synthesis, Antiproliferative Activity, and β-Tubulin Alkylation Kinetics
2003 · Emmanuelle Mounetou, Jean Legault, et al. · Journal of Medicinal Chemistry · 38
Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site
2007 · Jessica S. Fortin, Jacques Lacroix, et al. · Bioorganic & Medicinal Chemistry · 35
1-Aryl-3-(2-chloroethyl) Ureas: Synthesis and In Vitro Assay as Potential Anticancer Agents
1988 · R.C. Gaudreault, J. Lacroix, et al. · Journal of Pharmaceutical Sciences · 33
Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells
2017 · Sébastien Fortin, Xavier Charest-Morin, et al. · Journal of Medicinal Chemistry · 31
Synthesis and cytotoxic activity of new alkyl[3-(2-chloroethyl)ureido]benzene derivatives
1994 · P Béchard, J Lacroix, et al. · European Journal of Medicinal Chemistry · 30
Lack of cross-resistance to a new cytotoxic arylchloroethyl urea in various drug-resistant tumor cells
1994 · Ren� C.-Gaudreault, Moulay A. Alaoui-Jamali, et al. · Cancer Chemotherapy and Pharmacology · 29
New Soft Alkylating Agents with Enhanced Cytotoxicity against Cancer Cells Resistant to Chemotherapeutics and Hypoxia
2007 · Alexandre Patenaude, Réna G. Deschesnes, et al. · Cancer Research · 28
N-Phenyl-N′-(2-chloroethyl)urea analogues of combretastatin A-4: Is the N-phenyl-N′-(2-chloroethyl)urea pharmacophore mimicking the trimethoxy phenyl moiety?
2007 · Sébastien Fortin, Emmanuel Moreau, et al. · Bioorganic & Medicinal Chemistry Letters · 28
Synthesis, Biological Evaluation, and Structure–Activity Relationships of Novel Substituted N -Phenyl Ureidobenzenesulfonate Derivatives Blocking Cell Cycle Progression in S-Phase and Inducing DNA Double-Strand Breaks
2012 · Vanessa Turcotte, Sébastien Fortin, et al. · Journal of Medicinal Chemistry · 25
In vitro activity of novel dual action MDR anthranilamide modulators with inhibitory activity at CYP-450
2006 · Philippe Labrie, Shawn. P. Maddaford, et al. · Bioorganic & Medicinal Chemistry · 25
Imidazonaphthyridine systems (part 2): Functionalization of the phenyl ring linked to the pyridine pharmacophore and its replacement by a pyridinone ring produces intriguing differences in cytocidal activity
2012 · Nicolas Masurier, Eric Debiton, et al. · European Journal of Medicinal Chemistry · 24
Erythrocyte membrane-bound daunorubicin as a delivery system in anticancer treatment.
1989 · R C Gaudreault, B Bellemare, et al. · PubMed · 24
N-Phenyl-N′-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: Role of ω-hydroxyl group in the covalent binding to β-tubulin
2006 · Sébastien Fortin, Emmanuel Moreau, et al. · Bioorganic & Medicinal Chemistry · 22
Styryl-N-phenyl-N′-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model
2015 · Mathieu Gagné-Boulet, Sébastien Fortin, et al. · European Journal of Medicinal Chemistry · 19
In vitro and in vivo activity of 1-aryl-3-(2-chloroethyl) urea derivatives as new antineoplastic agents.
1988 · J Lacroix, R C Gaudreault, et al. · PubMed · 19
Characterization of the Covalent Binding of N-Phenyl-N′-(2-chloroethyl)ureas to β-Tubulin: Importance of Glu198 in Microtubule Stability
2010 · Sébastien Fortin, Bernadette Bouchon, et al. · Journal of Pharmacology and Experimental Therapeutics · 18
Works count: 53
Citation count: 1,091
H-index: 22
I10-index: 33
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