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Olivier Geneste

Functional and physical interaction between Bcl‐XL and a BH3‐like domain in Beclin‐1
2007 · M Chiara Maiuri, Gaëtane Le Toumelin, et al. · The EMBO Journal · 1,154
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The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models
2016 · András Kotschy, Zoltán Szlavik, et al. · Nature · 1,075
BH3-Only Proteins and BH3 Mimetics Induce Autophagy by Competitively Disrupting the Interaction between Beclin 1 and Bcl-2/Bcl-XL
2007 · Maria Chiara Maiuri, Alfredo Criollo, et al. · Autophagy · 448
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Decoding and unlocking the BCL-2 dependency of cancer cells
2013 · Philippe Juin, Olivier Geneste, et al. · Nature reviews. Cancer · 254
Activation of SRF-Regulated Chromosomal Templates by Rho-Family GTPases Requires a Signal that Also Induces H4 Hyperacetylation
1998 · Arthur S Alberts, Olivier Geneste, et al. · Cell · 227
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An improved fluorometric assay for dosimetry of benzo(a)pyrene diol-epoxide-DNA adducts in smokers' lung: comparisons with total bulky adducts and aryl hydrocarbon hydroxylase activity.
1992 · K Alexandrov, M Rojas, et al. · PubMed · 212
LIM kinase and Diaphanous cooperate to regulate serum response factor and actin dynamics
2002 · Olivier Geneste, John W. Copeland, et al. · The Journal of Cell Biology · 207
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Synergistic action of the MCL-1 inhibitor S63845 with current therapies in preclinical models of triple-negative and HER2-amplified breast cancer
2017 · Delphine Merino, James R. Whittle, et al. · Science Translational Medicine · 195
Combining BH3-mimetics to target both BCL-2 and MCL1 has potent activity in pre-clinical models of acute myeloid leukemia
2018 · Donia M. Moujalled, Giovanna Pomilio, et al. · Leukemia · 176
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Bax activation by the BH3-only protein Puma promotes cell dependence on antiapoptotic Bcl-2 family members
2009 · Tristan Gallenne, Fabien Gautier, et al. · The Journal of Cell Biology · 153
High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N‐nitrosodimethylamine and N‐nitrosodiethylamine in mice and humans
1993 · Anne‐Marie Camus, Olivier Geneste, et al. · Molecular Carcinogenesis · 147
The Small Organic Compound HA14-1 Prevents Bcl-2 Interaction with Bax to Sensitize Malignant Glioma Cells to Induction of Cell Death
2006 · Florence Manero, Fabien Gautier, et al. · Cancer Research · 135
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Cell Cycle-Dependent Induction of Autophagy, Mitophagy and Reticulophagy
2007 · Ezgi Tasdemir, M. Chiara Maiuri, et al. · Cell Cycle · 125
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S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth
2018 · Patrick Casara, James Davidson, et al. · Oncotarget · 119
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Discovery of S64315, a Potent and Selective Mcl-1 Inhibitor
2020 · Zoltan Szlavik, Marton Csekei, et al. · Journal of Medicinal Chemistry · 118
Various mechanisms cause RET-mediated signaling defects in Hirschsprung's disease.
1998 · A Pelet, O Geneste, et al. · Journal of Clinical Investigation · 102
Oncogenic activation of RET by two distinct FMTC mutations affecting the tyrosine kinase domain
1997 · Andrea Pasini, Olivier Geneste, et al. · Oncogene · 100
Comparison of pulmonary DNA adduct levels, measured by 32P-postlabelling and aryl hydrocarbon hydroxylase activity in lung parenchyma of smokers and ex-smokers
1991 · O. Geneste, A.-M. Camus, et al. · Carcinogenesis · 81
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity
2019 · Zoltan Szlávik, Levente Ondi, et al. · Journal of Medicinal Chemistry · 79
Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1
2019 · James B. Murray, James Davidson, et al. · ACS Omega · 77
Shooting at survivors: Bcl-2 family members as drug targets for cancer
2003 · Philippe Juin, Olivier Geneste, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 67
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Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site
1999 · O Geneste · Human Molecular Genetics · 58
Targeting Bcl-2/Bcl-XL Induces Antitumor Activity in Uveal Melanoma Patient-Derived Xenografts
2014 · Fariba Némati, Catherine de Montrion, et al. · PLoS ONE · 51
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Cytochrome P450 2a of nasal epithelium: Regulation and role in carcinogen metabolism
1995 · Jean‐Claude Béréziat, Francoise Raffalli, et al. · Molecular Carcinogenesis · 49
Radiosensitization by a novel Bcl-2 and Bcl-XL inhibitor S44563 in small-cell lung cancer
2014 · Y Loriot, P Mordant, et al. · Cell Death and Disease · 47
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Works count: 77
Citation count: 5,874
H-index: 31
I10-index: 40
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