Author

Toshihiko Nishiyama

Observed names: Nishiyama, Toshihiko, Toshihiko NISHIYAMA

Observed institutions: Ono Pharmaceutical (Japan), The University of Osaka

OpenAlex ID: A5110128550

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite

2006 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 48

Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability

2003 · Yasufumi Kawanaka, Kaoru Kobayashi, et al. · European Journal of Medicinal Chemistry · 23

Studies on novel and chiral 1,4-dihydropyridines. III. Asymmetric reduction of some ketones with novel NADH model compounds, (S)-3-(p-Tolylsulfinyl)-1,4-dihydropyridines

1997 · Satoshi Obika, Toshihiko Nishiyama, et al. · Tetrahedron · 22

Studies on novel and chiral 1,4-dihydropyridines. IV. Mechanistic aspects of the asymmetric reduction with chiral NADH model compounds, (S)-3-(p-tolylsulfinyl)-1,4-dihydropyridines

1997 · Satoshi Obika, Toshihiko Nishiyama, et al. · Tetrahedron · 20

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

2010 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry · 18

Design and Synthesis of Orally Bioavailable Inhibitors of Inducible Nitric Oxide Synthase. Identification of 2-Azabicyclo[4.1.0]heptan-3-imines

2003 · Yasufumi Kawanaka, Kaoru Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 18

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-Tetrahydro-2H-azepin-2-imines

2003 · Yasufumi Kawanaka, Kaoru Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 18

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles

2009 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 17

Studies on Novel and Chiral 1,4-Dihydropyridines. I. Synthesis and Conformational Analysis of Novel NADH Model Compounds, N-Substituted (S)-3-(p-Tolylsulfinyl)-1,4-dihydropyridines.

1996 · Takeshi IMANISHI, Satoshi OBIKA, et al. · Chemical and Pharmaceutical Bulletin · 15

PDF

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines

2002 · Yasufumi Kawanaka, Kaoru Kobayashi, et al. · Bioorganic & Medicinal Chemistry Letters · 13

Syntheses of 1-Substituted (SS)-3-p-Tolylsulfinyl-1,4-dihydropyridines, Chiral NADH Model Compounds

1997 · Takeshi Imanishi, Satoshi Obika, et al. · Heterocycles · 13

Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: A highly potent orally available CCR5 selective antagonist

2011 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry · 11

Stereospecific 4-Hydrogen Transfer in the Asymmetric Reduction Using (SS)-3-(p-Tolylsulfinyl)-1,4-dihydropyridines, NADH Model Compounds

1996 · Satoshi Obika, Toshihiko Nishiyama, et al. · Chemistry Letters · 11

Spirodiketopiperazine-based CCR5 antagonist: Discovery of an antiretroviral drug candidate

2010 · Rena Nishizawa, Toshihiko Nishiyama, et al. · Bioorganic & Medicinal Chemistry Letters · 9

Studies on Novel and Chiral 1,4-Dihydropyridines. VI. Preparation of a Polymer-supported 1,4-Dihydropyridine Having a Chiral Sulfinyl Group and Its Application to Biomimetic Reduction

1998 · Takeshi Imanishi, Satoshi Obika, et al. · Heterocycles · 9

Discovery of new orally active prostaglandin D2 receptor antagonists

2011 · Maki Iwahashi, Atsushi Naganawa, et al. · Bioorganic & Medicinal Chemistry · 4

One Step Synthesis of Dihydropyridin-2-imines: Inhibitors of Inducible Nitric Oxide Synthase

2002 · Yasufumi Kawanaka, Kaoru Kobayashi, et al. · Synlett · 4

CCDC 1015735: Experimental Crystal Structure Determination

2014 · Iwahashi, Maki, Naganawa, Atsushi, et al. · The Cambridge Structural Database

CCDC 843498: Experimental Crystal Structure Determination

2014 · Iwahashi, Maki, Naganawa, Atsushi, et al. · The Cambridge Structural Database

ChemInform Abstract: Studies on Novel and Chiral 1,4‐Dihydropyridines. Part 6. Preparation of a Polymer‐Supported 1,4‐Dihydropyridine Having a Chiral Sulfinyl Group and Its Application to Biomimetic Reduction.

1999 · Satoshi Obika, Toshihiko Nishiyama, et al. · ChemInform

Works count: 20

Citation count: 273

H-index: 11

I10-index: 13