Author

BF Cravatt

Observed name: B. Cravatt

Observed institutions: Scripps Research Institute, Kojundo Chemical Laboratory Co., Ltd. (Japan)

OpenAlex ID: A5110420304

Inhibiting fatty acid amide hydrolase normalizes endotoxin‐induced enhanced gastrointestinal motility in mice

2011 · M Bashashati, MA Storr, et al. · British Journal of Pharmacology · 61

COX‐2 and fatty acid amide hydrolase can regulate the time course of depolarization‐induced suppression of excitation

2011 · A Straiker, J Wager‐Miller, et al. · British Journal of Pharmacology · 58

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

2010 · L Thors, JJ Burston, et al. · British Journal of Pharmacology · 46

Control of experimental spasticity by targeting the degradation of endocannabinoids using selective fatty acid amide hydrolase inhibitors

2013 · G Pryce, A Cabranes, et al. · Multiple Sclerosis Journal · 36

Probe Report for PME-1 Inhibitors

2010 · DA Bachovchin, AE Speers, et al. · 2

Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)

2011 · DA Bachovchin, AE Speers, et al. · Europe PMC (PubMed Central) · 1

Figure 8, Probe development strategy, post-uHTS

2014 · TD Bannister, H Wang, et al.

Figure 9, Benzoisothiazolones target a cysteine residue of IDE

2014 · TD Bannister, H Wang, et al.

Figure 5, 48 hour stability study of ML345 in PBS

2014 · TD Bannister, H Wang, et al.

Figure 7, Screening campaign overview

2014 · TD Bannister, H Wang, et al.

[Table], Batch data, IDE Inhibitor Probe

2014 · TD Bannister, H Wang, et al.

Figure 15, Prior art compounds

2014 · TD Bannister, Hui Wang, et al.

Table 2, Probe ML345 and Analogs

2014 · TD Bannister, H Wang, et al.

Figure 6, Synthesis of probe ML345

2014 · TD Bannister, H Wang, et al.

Figure 4, HPLC Spectrum of ML345 at various wavelengths; purity >98%

2014 · TD Bannister, H Wang, et al.

Table 1, IDE Inhibitor PubChem AIDs (click on hyperlink for details)

2014 · TD Bannister, H Wang, et al.

Table 4, CYP450 Inhibition of Probe ML345

2014 · TD Bannister, H Wang, et al.

Figure 2, IDE closed state, and open form of Pitrilysin

2014 · TD Bannister, Houlin Wang, et al.

Table 5, Abbreviated SAR summary in the probe scaffold showing cell-free (biochemical) results

2014 · TD Bannister, H Wang, et al.

Figure 12, Probe dose-response curve, IDE inhibition (AID 624065, SID 136920229)

2014 · TD Bannister, H Wang, et al.

Figure 14, Proteome-wide activity-based protein profiling for cysteine reactivity of ML345

2014 · TD Bannister, H Wang, et al.

Figure 11, ML345 is a fluorinated analog of CID 2325815

2014 · TD Bannister, H Wang, et al.

Figure 1, IDE schematic structure

2014 · TD Bannister, H Wang, et al.

Table 3, Hit summary, promiscuity analysis (reflects PubChem data available at time of uHTS)

2014 · TD Bannister, H Wang, et al.

Figure 13, Lipiniski and other drug-likeness parameters for ML345

2014 · TD Bannister, Hanning Wang, et al.

Works count: 50

Citation count: 204

H-index: 4

I10-index: 4