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Hitoshi Iikura

The First Pentahaptofullerene Metal Complexes
1996 · Masaya Sawamura, Hitoshi Iikura, et al. · Journal of the American Chemical Society · 271
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor
2023 · Mikimasa Tanada, Minoru Tamiya, et al. · Journal of the American Chemical Society · 197
Enhanced Inhibition of ERK Signaling by a Novel Allosteric MEK Inhibitor, CH5126766, That Suppresses Feedback Reactivation of RAF Activity
2013 · Nobuya Ishii, Naoki Harada, et al. · Cancer Research · 182
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets
2023 · Atsushi Ohta, Mikimasa Tanada, et al. · Journal of the American Chemical Society · 121
Structural Variation in Manganase Complexes: Synthesis and Characterization of Manganese Complexes from Carboxylate-containing Chelating Ligands
1998 · Hitoshi Iikura, Toshi Nagata · Inorganic Chemistry · 102
Endohedral Homoconjugation in Cyclopentadiene Embedded in C60. Theoretical and Electrochemical Evidence
1997 · Hitoshi Iikura, Seiji Mori, et al. · The Journal of Organic Chemistry · 95
Design and synthesis of novel allosteric MEK inhibitor CH4987655 as an orally available anticancer agent
2011 · Yoshiaki Isshiki, Yasunori Kohchi, et al. · Bioorganic & Medicinal Chemistry Letters · 81
Synthesis of π-Indenyl-type Fullerene Ligand and Its Metal Complexes via Quantitative Trisarylation of C70
1998 · Masaya Sawamura, Hitoshi Iikura, et al. · Journal of the American Chemical Society · 77
Single-step synthesis of pentaaryl-monohydro[60]fullerenes through fivefold addition of organocopper reagent to C60
2000 · Masaya Sawamura, Hitoshi Iikura, et al. · Journal of Organometallic Chemistry · 61
Stepwise Synthesis of Fullerene Cyclopentadienide R5C60- and Indenide R3C60-. An Approach to Fully Unsymmetrically Substituted Derivatives
2000 · Masaya Sawamura, Motoki Toganoh, et al. · Organic Letters · 44
Fluorine Scanning by Nonselective Fluorination: Enhancing Raf/MEK Inhibition while Keeping Physicochemical Properties
2013 · Ikumi Hyohdoh, Noriyuki Furuichi, et al. · ACS Medicinal Chemistry Letters · 41
Broadly Applicable and Comprehensive Synthetic Method forN-Alkyl-Rich Drug-like Cyclic Peptides
2022 · Kenichi Nomura, Satoshi Hashimoto, et al. · Journal of Medicinal Chemistry · 37
Cu(i)-mediated regioselective tri-addition of Grignard reagent to [70]fullerene. Synthesis of indenyl-type metal ligand embedded into graphitic structure
2002 · Masaya Sawamura, Motoki Toganoh, et al. · Journal of Materials Chemistry · 30
Optimizing the Physicochemical Properties of Raf/MEK Inhibitors by Nitrogen Scanning
2014 · Toshihiro Aoki, Ikumi Hyohdoh, et al. · ACS Medicinal Chemistry Letters · 26
The sulfamide moiety affords higher inhibitory activity and oral bioavailability to a series of coumarin dual selective RAF/MEK inhibitors
2013 · Toshihiro Aoki, Ikumi Hyohdoh, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Structure-activity relationships of middle-size cyclic peptides, KRAS inhibitors derived from an mRNA display
2024 · Mirai Kage, Ryuji Hayashi, et al. · Bioorganic & Medicinal Chemistry · 15
Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination
2008 · Takuya Shiraishi, Shojiro Kadono, et al. · Bioorganic & Medicinal Chemistry Letters · 14
Abstract 1654: Anti-tumor activity of orally-available cyclic peptide LUNA18 through direct RAS inhibition in RAS-altered tumors
2024 · Hitoshi Sase, Saki Michisaka, et al. · Cancer Research · 8
Antitumor Activity of Orally Available Cyclic Peptide LUNA18 through Direct Pan-RAS Inhibition across Diverse RAS Genetic Alterations
2026 · Hitoshi Sase, Saki Michisaka, et al. · Molecular Cancer Therapeutics · 3
Abstract 1664: Combination of LUNA18, a novel RAS inhibitor, with KRAS G12C inhibitors augments anti-tumor activity via inhibition of MAPK pathway reactivation
2024 · Saki Michisaka, Hitoshi Sase, et al. · Cancer Research · 3
Structure-Based Drug Design of Peptide Mimetics Containing Large P3 Moieties as Inhibitors of Factor VIIa
2009 · Takuya Shiraishi, Shojiro Kadono, et al. · Letters in Drug Design & Discovery · 2
Abstract 2789: Discovery of a novel specific MEK and Raf inhibitor, CH5126766 (RO5126766), hit to lead study of a unique scaffold for kinase inhibitor to a clinical compound
2011 · Hitoshi Iikura, Toshihiro Aoki, et al. · Cancer Research · 1
Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors
2010 · Takuya Shiraishi, Shojiro Kadono, et al. · Chemical and Pharmaceutical Bulletin · 1
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Syntheses of Transition Metal Nitride Complexes
2000 · Craig S. Tomooka, Hitoshi Iikura, et al. · Wiley eBooks · 1
Exploiting Bridged Conformations for Precise Molecular Recognition in the Design of KRAS-Selective, Orally Available Macrocyclic Peptides
2026 · Mirai Kage, Hatsuo Kawada, et al. · Journal of the American Chemical Society
Works count: 43
Citation count: 1,435
H-index: 15
I10-index: 17
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