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Author

Yanying Sun

ORCID: 0009-0008-4205-3924
Observed ORCID: 0009-0008-4205-3924
OpenAlex ID: A5111155310
Structure-Based Bioisosterism Yields HIV‑1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties
2020 · Dongwei Kang, Da Feng, et al. · Journal of Medicinal Chemistry · 74
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Exploring the hydrophobic channel of NNIBP leads to the discovery of novel piperidine-substituted thiophene[3,2-d]pyrimidine derivatives as potent HIV-1 NNRTIs
2019 · Dongwei Kang, Da Feng, et al. · Acta Pharmaceutica Sinica B · 53
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2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies
2021 · Dongwei Kang, Francesc X. Ruiz, et al. · Journal of Medicinal Chemistry · 50
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel
2020 · Dongwei Kang, F. Xavier Ruiz, et al. · Journal of Medicinal Chemistry · 46
An arabinogalactan from Lycium barbarum mitigated DSS caused intestinal injury via inhibiting mucosal damage and regulating the gut microbiota disorder
2024 · Jiaojiao Mou, Jie Yang, et al. · Carbohydrate Polymers · 35
In situ click chemistry-based rapid discovery of novel HIV-1 NNRTIs by exploiting the hydrophobic channel and tolerant regions of NNIBP
2020 · Dongwei Kang, Da Feng, et al. · European Journal of Medicinal Chemistry · 31
Fucosylated chondroitin sulfate from sea cucumber Stichopus chloronotus alleviate the intestinal barrier injury and oxidative stress damage in vitro and in vivo
2023 · Huanan Yin, Rui Li, et al. · Carbohydrate Polymers · 29
Boronic acid-containing diarylpyrimidine derivatives as novel HIV-1 NNRTIs: Design, synthesis and biological evaluation
2021 · Da Feng, Fenju Wei, et al. · Chinese Chemical Letters · 23
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Development of Novel Dihydrofuro[3,4- d ]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C
2022 · Dongwei Kang, Yanying Sun, et al. · Journal of Medicinal Chemistry · 21
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Fucoidan from Stichopus chloronotus relieved DSS induced ulcerative colitis through inhibiting intestinal barrier disruption and oxidative stress
2024 · Rui Li, Jiaojiao Mou, et al. · International Journal of Biological Macromolecules · 19
In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket
2023 · Yanying Sun, Da Feng, et al. · Bioorganic & Medicinal Chemistry · 18
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs
2022 · Yanying Sun, Zhenzhen Zhou, et al. · Journal of Medicinal Chemistry · 15
Structure–Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs
2020 · Dongwei Kang, Yanying Sun, et al. · ACS Infectious Diseases · 15
Long-range neuropeptide relay as a central-peripheral communication mechanism for the context-dependent modulation of interval timing behaviors
2024 · Tianmu Zhang, Zekun Wu, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 11
Disubstituted pyrimidine-5-carboxamide derivatives as novel HIV-1 NNRTIs: Crystallographic overlay-based molecular design, synthesis, and biological evaluation
2022 · Da Feng, Hao Lin, et al. · European Journal of Medicinal Chemistry · 11
Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP
2021 · Tao Zhang, Zhongxia Zhou, et al. · Bioorganic Chemistry · 11
Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket
2021 · Yanying Sun, Dongwei Kang, et al. · European Journal of Medicinal Chemistry · 11
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Genetic screening reveals cone cell-specific factors as common genetic targets modulating rival-induced prolonged mating in male Drosophila melanogaster
2024 · Yanying Sun, Xiaoli Zhang, et al. · G3 Genes Genomes Genetics · 9
Neuropeptide-mediated synaptic plasticity regulates context-dependent mating behaviors in Drosophila
2025 · Tianmu Zhang, Zekun Wu, et al. · PLoS Biology · 8
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Discovery of 2,4,6-trisubstituted pyrimidine derivatives as novel potent HIV-1 NNRTIs by exploiting the tolerant region II of the NNIBP
2024 · Zhenzhen Zhou, Yanying Sun, et al. · European Journal of Medicinal Chemistry · 8
Design and optimization of piperidine-substituted thiophene[3,2-d]pyrimidine-based HIV-1 NNRTIs with improved drug resistance and pharmacokinetic profiles
2024 · Yanying Sun, Zhenzhen Zhou, et al. · Acta Pharmaceutica Sinica B · 8
Investigating the immunomodulatory effects of honeybee venom peptide apamin in Drosophila platforms
2025 · Yanan Wei, Wenjie Jia, et al. · Infection and Immunity · 7
Discovery of potent HIV-1 NNRTIs by CuAAC click-chemistry-based miniaturized synthesis, rapid screening and structure optimization
2024 · Lanlan Jing, Gaochan Wu, et al. · European Journal of Medicinal Chemistry · 7
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs
2024 · Yanying Sun, Zhenzhen Zhou, et al. · Journal of Medicinal Chemistry · 7
Structure-Based Design of Novel G-Protein-Coupled Receptor TAAR1 Agonists as Potential Antipsychotic Drug Candidates
2024 · Zhenzhen Zhou, Weifeng Zhang, et al. · Journal of Medicinal Chemistry · 7
Works count: 42
Citation count: 559
H-index: 13
I10-index: 17
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