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Ken Grime

Observed names: K Grime, K. Grime, K. H. Grime, Kenneth Grime, Kenneth H. Grime
Observed institutions: AstraZeneca (United Kingdom), University of Nottingham, Karolinska Institutet, Servier (United Kingdom), AstraZeneca (Sweden), University of Birmingham
OpenAlex ID: A5111701733
The pivotal role of hepatocytes in drug discovery
2006 · Matthew G. Soars, Dermot F. McGinnity, et al. · Chemico-Biological Interactions · 173
Use of Hepatocytes to Assess the Contribution of Hepatic Uptake to Clearance in Vivo
2007 · Matthew G. Soars, Ken Grime, et al. · Drug Metabolism and Disposition · 144
Time-dependent CYP inhibition
2007 · Robert J Riley, Ken Grime, et al. · Expert Opinion on Drug Metabolism & Toxicology · 135
Improving the Accuracy of Predicted Human Pharmacokinetics: Lessons Learned from the AstraZeneca Drug Pipeline Over Two Decades
2020 · Michael Davies, Rhys D.O. Jones, et al. · Trends in Pharmacological Sciences · 122
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The Impact of In Vitro Binding on In Vitro - In Vivo Extrapolations, Projections of Metabolic Clearance and Clinical Drug-Drug Interactions
2006 · K. Grime, R. Riley · Current Drug Metabolism · 112
Optimisation of DMPK by the Inhaled Route: Challenges and Approaches
2012 · Anne E. Cooper, Douglas Ferguson, et al. · Current Drug Metabolism · 104
Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug
2013 · Md L T Vieira, B Kirby, et al. · Clinical Pharmacology & Therapeutics · 102
Evaluation of Time-dependent Cytochrome P450 Inhibition Using Cultured Human Hepatocytes
2006 · Dermot F. McGinnity, Amanda J. Berry, et al. · Drug Metabolism and Disposition · 99
Automated Assessment of Time-dependent Inhibition of Human Cytochrome P450 Enzymes Using Liquid Chromatography-tandem Mass Spectrometry Analysis
2005 · Anthony Atkinson, Jane R. Kenny, et al. · Drug Metabolism and Disposition · 96
Determination of Human Hepatocyte Intrinsic Clearance for Slowly Metabolized Compounds: Comparison of a Primary Hepatocyte/Stromal Cell Co-culture with Plated Primary Hepatocytes and HepaRG
2016 · Britta Bonn, Petter Svanberg, et al. · Drug Metabolism and Disposition · 93
Mechanism-based inhibition of cytochrome P450 enzymes: An evaluation of early decision making in vitro approaches and drug–drug interaction prediction methods
2008 · Kenneth H. Grime, James Bird, et al. · European Journal of Pharmaceutical Sciences · 91
Application of In Silico, In Vitro and Preclinical Pharmacokinetic Data for the Effective and Efficient Prediction of Human Pharmacokinetics
2012 · Kenneth H. Grime, Patrick Barton, et al. · Molecular Pharmaceutics · 78
HepaRG Cells as Human-Relevant In Vitro Model to Study the Effects of Inflammatory Stimuli on Cytochrome P450 Isoenzymes
2014 · Katarina Rubin, Annika Janefeldt, et al. · Drug Metabolism and Disposition · 56
Species Differences in Biliary Clearance and Possible Relevance of Hepatic Uptake and Efflux Transporters Involvement
2012 · Ken Grime, Stuart W. Paine · Drug Metabolism and Disposition · 56
Metabolic screening in vitro: metabolic stability, CYP inhibition and induction
2004 · Robert J. Riley, Ken Grime · Drug Discovery Today Technologies · 56
Preclinical Development Handbook: ADME and Biopharmaceutical Properties
2007 · Harvey J. Clewell, Robert J. Riley, et al. · 47
Exploring concepts ofin vitrotime-dependent CYP inhibition assays
2013 · David M Stresser, Jialin Mao, et al. · Expert Opinion on Drug Metabolism & Toxicology · 42
Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5
2006 · M. G. Soars, K. Grime, et al. · Xenobiotica · 40
Translational Model to Predict Pulmonary Pharmacokinetics and Efficacy in Man for Inhaled Bronchodilators
2017 · Ramon Hendrickx, Eva Lamm Bergström, et al. · CPT Pharmacometrics & Systems Pharmacology · 38
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The Development of a Cocktail CYP2B6, CYP2C8, and CYP3A5 Inhibition Assay and a Preliminary Assessment of Utility in a Drug Discovery Setting
2006 · Charles J. O’Donnell, Ken Grime, et al. · Drug Metabolism and Disposition · 37
In Vitro ADME Profiling of PROTACs: Successes, Challenges, and Lessons Learned from Analysis of Clinical PROTACs from a Diverse Physicochemical Space
2025 · Abhishek Srivastava, Andy Pike, et al. · Journal of Medicinal Chemistry · 32
The Use of HepaRG and Human Hepatocyte Data in Predicting CYP Induction Drug-Drug Interactions via Static Equation and Dynamic Mechanistic Modelling Approaches
2010 · Ken Grime, Douglas D. Ferguson, et al. · Current Drug Metabolism · 30
Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles
2023 · Sabha Asghar, Susan Monkley, et al. · Respiratory Research · 29
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Plasma Protein Binding as an Optimizable Parameter for Acidic Drugs
2019 · Philip Gardiner, Rhona J. Cox, et al. · Drug Metabolism and Disposition · 29
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Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes
2008 · Ken Grime, Peter J.H. Webborn, et al. · Drug Metabolism and Disposition · 27
Works count: 63
Citation count: 2,243
H-index: 26
I10-index: 42
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