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Inge Lues

Safety, tolerability and efficacy of the glutaminyl cyclase inhibitor PQ912 in Alzheimer’s disease: results of a randomized, double-blind, placebo-controlled phase 2a study
2018 · Philip Scheltens, Merja Hallikainen, et al. · Alzheimer s Research & Therapy · 134
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The Two Mechanisms of Action of Racemic Cardiotonic EMD 53998, Calcium Sensitization and Phosphodiesterase Inhibition, Reside in Different Enantiomers
1993 · Inge Lues, Norbert Beier, et al. · Journal of Cardiovascular Pharmacology · 80
Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer’s Disease—Studies on Relation to Effective Target Occupancy
2017 · Torsten Hoffmann, Antje Meyer, et al. · Journal of Pharmacology and Experimental Therapeutics · 77
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Postjunctional ?-adrenoceptors in the isolated saphenous vein of the rabbit
1983 · Hans-Joachim Sch�mann, Inge Lues · Naunyn-Schmiedeberg s Archives of Pharmacology · 67
The Novel Cardiotonic Agent EMD 53 998 is a Potent “Calcium Sensitizer”
1991 · Norbert Beier, Juergen Harting, et al. · Journal of Cardiovascular Pharmacology · 65
An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice
2015 · Jeffrey L. Frost, Bin Liu, et al. · Neurobiology of Aging · 64
Effect of removing the endothelial cells on the reactivity of rat aortic segments to different ?-adrenoceptor agonists
1984 · Inge Lues, Hans-Joachim Sch�mann · Naunyn-Schmiedeberg s Archives of Pharmacology · 63
A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects
2015 · Inge Lues, Frank Weber, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 62
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3-Methyl-2H-1-benzopyran potassium channel activators
1991 · Rolf Gericke, Juergen Harting, et al. · Journal of Medicinal Chemistry · 62
Effector function of anti-pyroglutamate-3 Aβ antibodies affects cognitive benefit, glial activation and amyloid clearance in Alzheimer’s-like mice
2020 · Helen Crehan, Bin Liu, et al. · Alzheimer s Research & Therapy · 48
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Passive Aβ Immunotherapy: Current Achievements and Future Perspectives
2018 · Stephan Schilling, Jens-Ulrich Rahfeld, et al. · Molecules · 48
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Thyroid-dependent alterations of myocardial adrenoceptors and adrenoceptor-mediated responses in the rat
1985 · Gerhard Gross, Inge Lues · Naunyn-Schmiedeberg s Archives of Pharmacology · 43
A New Cardiotonic Drug Reduces the Energy Cost of Active Tension in Cardiac Muscle
1993 · Tobias Groß, Inge Lues, et al. · Journal of Molecular and Cellular Cardiology · 38
Development of the clinical candidate PBD-C06, a humanized pGlu3-Aβ-specific antibody against Alzheimer’s disease with reduced complement activation
2020 · Thore Hettmann, Stephen D. Gillies, et al. · Scientific Reports · 29
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Effect of isomazole on the responsiveness to calcium of the contractile elements in skinned cardiac muscle fibres of various species
1988 · Inge Lues, Renate Siegel, et al. · European Journal of Pharmacology · 29
Structural and functional analyses of pyroglutamate-amyloid-β-specific antibodies as a basis for Alzheimer immunotherapy
2017 · Anke Piechotta, Christoph Parthier, et al. · Journal of Biological Chemistry · 28
Glutaminyl cyclase activity correlates with levels of Aβ peptides and mediators of angiogenesis in cerebrospinal fluid of Alzheimer’s disease patients
2017 · Claire Bridel, Torsten Hoffmann, et al. · Alzheimer s Research & Therapy · 27
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B-HT 920 acts as an ? 1-adrenoceptor agonist in the rabbit aorta under certain in vitro conditions
1984 · Inge Lues, Hans-Joachim Sch�mann · Naunyn-Schmiedeberg s Archives of Pharmacology · 27
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aβ Pathology in Transgenic Mice
2021 · Torsten Hoffmann, Jens-Ulrich Rahfeld, et al. · International Journal of Molecular Sciences · 20
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Immunohistochemical Evidence from APP-Transgenic Mice for Glutaminyl Cyclase as Drug Target to Diminish pE-Abeta Formation
2018 · Maike Hartlage-Rübsamen, Alexandra Bluhm, et al. · Molecules · 19
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Calcium Sensitization as a Positive Inotropic Mechanism in Diseased Rat and Human Heart
1994 · Richard Nankervis, Inge Lues, et al. · Journal of Cardiovascular Pharmacology · 19
The transformation of a chromene derivative into benzofurans via allene intermediates
1992 · Rolf Gericke, Inge Lues · Tetrahedron Letters · 18
In Vivo Evidence of Positive Inotropism of EMD 57 033 Through Calcium Sensitization
1997 · Guenther Haeusler, Rochus Jonas, et al. · Journal of Cardiovascular Pharmacology · 15
Stereoselectivity of actions of the calcium sensitizer [+]-EMD 60263 and its enantiomer [-]-EMD 60264
1997 · U. Ravens, Michael O. Flüß, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 14
Influence of hypo- and hyperthyroidism on plasma catecholamines in pithed rats
1981 · Marianne Nagel-Hiemke, Gerhard Gro�, et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 14
Works count: 51
Citation count: 1,146
H-index: 19
I10-index: 27
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