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Leonard Μ. Neckers

Observed names: L M Neckers, LEONARD M. NECKERS, LEONARD NECKERS, Leonard M Neckers, Leonard M. Neckers, Leonard Neckers
Observed institutions: National Institutes of Health, Karolinska University Hospital, University of Connecticut, Georgetown University, Kyoto University, Government of the United States of America, St. Elizabeths Hospital, Karolinska Institutet, University of Alabama at Birmingham, National Institute of Neurological Disorders and Stroke, National Cancer Institute, National Cancer Institute, National Institute of Allergy and Infectious Diseases, National Cancer Institute, Center for Cancer Research, National Institute of Mental Health, Instituto Nacional del Cáncer, Georgetown Lombardi Comprehensive Cancer Center, Pusan National University
ORCID: 0000-0001-9639-7249
Observed ORCID: 0000-0001-9639-7249
OpenAlex ID: A5113399692
Stabilization of wild-type p53 by hypoxia-inducible factor 1α
1998 · Won G. An, Meera Kanekal, et al. · Nature · 827
A c-myc antisense oligodeoxynucleotide inhibits entry into S phase but not progress from G0 to G1
1987 · Reino Heikkila, Gisela Schwab, et al. · Nature · 683
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
2002 · Jennifer S. Isaacs, Yun-Jin Jung, et al. · Journal of Biological Chemistry · 663
The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation
1997 · James P. Grenert, William P. Sullivan, et al. · Journal of Biological Chemistry · 569
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The Heat Shock Protein 90 Antagonist Novobiocin Interacts with a Previously Unrecognized ATP-binding Domain in the Carboxyl Terminus of the Chaperone
2000 · Monica G. Marcu, Ahmed Chadli, et al. · Journal of Biological Chemistry · 502
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
1998 · Theodor W. Schulte, Leonard M. Neckers · Cancer Chemotherapy and Pharmacology · 478
Novobiocin and Related Coumarins and Depletion of Heat Shock Protein 90-Dependent Signaling Proteins
2000 · Monica G. Marcu, Theodore W. Schulte, et al. · JNCI Journal of the National Cancer Institute · 405
Antibiotic radicicol binds to the N-terminal domain of Hsp90 and shares important biologic activities with geldanamycin
1998 · Theodor W. Schulte, Shiro Akinaga, et al. · Cell Stress and Chaperones · 403
Molecular chaperone TRAP1 regulates a metabolic switch between mitochondrial respiration and aerobic glycolysis
2013 · Soichiro Yoshida, Shinji Tsutsumi, et al. · Proceedings of the National Academy of Sciences · 280
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Destabilization of Raf-1 by Geldanamycin Leads to Disruption of the Raf-1–MEK–Mitogen-Activated Protein Kinase Signalling Pathway
1996 · Theodor W. Schulte, Mikhail V. Blagosklonny, et al. · Molecular and Cellular Biology · 269
The heat shock protein 90 antagonist geldanamycin alters chaperone association with p210bcr-abl and v-src proteins before their degradation by the proteasome.
2000 · W G An, T W Schulte, et al. · PubMed · 265
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 + T cell stemness and antitumor immunity
2020 · Dalton Hermans, Sanjivan Gautam, et al. · Proceedings of the National Academy of Sciences · 229
Geldanamycin-Induced Destabilization of Raf-1 Involves the Proteasome
1997 · Theodor W. Schulte, Won G. An, et al. · Biochemical and Biophysical Research Communications · 190
Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer
2012 · Qing Cheng, Jeffrey T Chang, et al. · Breast Cancer Research · 183
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Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity.
2003 · Kheem S Bisht, C Matthew Bradbury, et al. · PubMed · 178
Interaction of Radicicol with Members of the Heat Shock Protein 90 Family of Molecular Chaperones
1999 · Theodor W. Schulte, Shiro Akinaga, et al. · Molecular Endocrinology · 161
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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH)
2017 · Ganesha Rai, Kyle R. Brimacombe, et al. · Journal of Medicinal Chemistry · 152
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Plasma levels of chlorimipramine and its demethyl metabolite during treatment of depression
1979 · Lil Träskman, Marie Åsberg, et al. · Clinical Pharmacology & Therapeutics · 142
Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells
2011 · Johanny Tonos De Leon, Aki Iwai, et al. · Proceedings of the National Academy of Sciences · 132
Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma
2019 · Choh Yeung, Anna E. Gibson, et al. · Cancer Research · 131
Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy
2020 · Nobu Oshima, Ryo Ishida, et al. · Cell Reports · 125
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Mitochondrial Topoisomerase I (Top1mt) Is a Novel Limiting Factor of Doxorubicin Cardiotoxicity
2014 · Salim Khiati, Ilaria Dalla Rosa, et al. · Clinical Cancer Research · 124
Charged linker sequence modulates eukaryotic heat shock protein 90 (Hsp90) chaperone activity
2012 · Shinji Tsutsumi, Mehdi Mollapour, et al. · Proceedings of the National Academy of Sciences · 124
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Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer
2018 · Michael A. Moses, Yeong Sang Kim, et al. · Cancer Research · 120
STA-9090, a small-molecule Hsp90 inhibitor for the potential treatment of cancer.
2010 · Yisong Wang, Jane B Trepel, et al. · PubMed · 111
Works count: 289
Citation count: 10,460
H-index: 52
I10-index: 92
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