Author

Maria L. Maccecchini

Observed names: M L Maccecchini, M. L. Maccecchini, M. Maccecchini, M.-L. Maccecchini, M.L. Maccecchini, M.‐L. MACCECCHINI, Maria L Maccecchini, Maria Luisa MACCECCHINI, Maria Maccecchini, Maria-Luisa Maccecchini

Observed institutions: National Institutes of Health, Pennsylvania State University, University of Basel, National Institute of Diabetes and Digestive and Kidney Diseases, QR Pharma (United States), Catalent (United States), X4 Pharmaceuticals, Inc. (United States)

ORCID: 0000-0003-1467-8675

Observed ORCID: 0000-0003-1467-8675

OpenAlex ID: A5113571789

Import of proteins into mitochondria: precursor forms of the extramitochondrially made F1-ATPase subunits in yeast.

1979 · M L Maccecchini, Y Rudin, et al. · Proceedings of the National Academy of Sciences · 453

Posiphen as a candidate drug to lower CSF amyloid precursor protein, amyloid-β peptide and τ levels: target engagement, tolerability and pharmacokinetics in humans

2012 · Maria L Maccecchini, Mee Young Chang, et al. · Journal of Neurology Neurosurgery & Psychiatry · 94

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Transport of proteins across the mitochondrial outer membrane. A precursor form of the cytoplasmically made intermembrane enzyme cytochrome c peroxidase.

1979 · M.L. Maccecchini, Y. Rudin, et al. · Journal of Biological Chemistry · 94

The alpha-synuclein 5′untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

2011 · Jack T. Rogers, Sohan Mikkilineni, et al. · Journal of Neural Transmission · 83

Synthesis, Resolution, and Biological Evaluation of the Four Stereoisomers of 4-Methylglutamic Acid: Selective Probes of Kainate Receptors

1995 · Zi-Qiang Gu, David P. Hesson, et al. · Journal of Medicinal Chemistry · 74

Buntanetap, a Novel Translational Inhibitor of Multiple Neurotoxic Proteins, Proves to Be Safe and Promising in Both Alzheimer's and Parkinson's Patients

2022 · Cheng Fang, P. Hernandez, et al. · The Journal of Prevention of Alzheimer s Disease · 58

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Targeting increased levels of APP in Down syndrome: Posiphen‐mediated reductions in APP and its products reverse endosomal phenotypes in the Ts65Dn mouse model

2020 · Xu‐Qiao Chen, Ahmad Salehi, et al. · Alzheimer s & Dementia · 54

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Translational inhibition of APP by Posiphen: Efficacy, pharmacodynamics, and pharmacokinetics in the APP/PS1 mouse

2018 · Andrew F. Teich, Ekta Sharma, et al. · Alzheimer s & Dementia Translational Research & Clinical Interventions · 44

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Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist

1993 · P. Chandler, M. Pennington, et al. · Journal of Biological Chemistry · 44

The kainate receptor antagonist 2S,4R-4-methylglutamate attenuates mechanical allodynia and thermal hyperalgesia in a rat model of nerve injury

1999 · J.L. Sutton, M.-L. Maccecchini, et al. · Neuroscience · 41

Translational inhibition of α-synuclein by Posiphen normalizes distal colon motility in transgenic Parkinson mice.

2019 · Yien-Ming Kuo, Ejike Innocent Nwankwo, et al. · PubMed · 36

Plasma Somatotropin Response to Exogenous Growth Hormone Releasing Factor in Lambs1

1987 · R. S. Kensinger, L. M. McMunn, et al. · Journal of Animal Science · 20

A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer’s Disease

2024 · Douglas Galasko, Martin R. Farlow, et al. · Alzheimer s Research & Therapy · 17

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Posiphen Reduces the Levels of Huntingtin Protein through Translation Suppression

2021 · Xu-Qiao Chen, Carlos A. Barrero, et al. · Pharmaceutics · 17

SYM 2081, an agonist that desensitizes kainate receptors, attenuates capsaicin and inflammatory hyperalgesia

2003 · Michelle S. Turner, Darryl T. Hamamoto, et al. · Brain Research · 14

Synthesis and characterization of a disulfide bond isomer of omega-conotoxin GVIA

1992 · M.W. Pennington, S.M. Festin, et al. · Toxicon · 12

Sugar‐Specific Antibodies Reactive towards Cell‐Surface Carbohydrates

1977 · Robert BLOCH, Maria Luisa MACCECCHINI, et al. · European Journal of Biochemistry · 6

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HIV protease, chromogenic substrate and inhibitor

1991 · M. W. Pennington, S. M. Festin, et al. · Springer eBooks · 5

P4‐107: Posiphen'S Pharmacokinetics and Mechanism‐of‐action in Mildly Cognitive Impaired Patients

2010 · Maria L. Maccecchini · Alzheimer s & Dementia · 3

P1‐243: Posiphen lowers amyloid precursor protein and amyloid β as well as acetylcholinesterase levels in culture, animals and humans

2009 · Maria L. Maccecchini, Mark Roffman, et al. · Alzheimer s & Dementia · 3

Buntanetap treatment in mild to moderate Alzheimer’s disease: phase 2/3 study

2026 · Cheng Fang, David Feng, et al. · npj Dementia · 2

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Comparative Analysis of Posiphen Pharmacokinetics across Different Species—Similar Absorption and Metabolism in Mouse, Rat, Dog and Human

2024 · Maria L. Maccecchini, Diane R. Mould · Biomolecules · 2

Comparison of folding procedures on synthetic ω-conotoxin

1991 · M. W. Pennington, S. M. Festin, et al. · Springer eBooks · 2

Stable Isotope Labelling Kinetics: Models and methods to evaluate APP production rates with Posiphen treatment in the DISCOVER clinical trial

2023 · Donald L Elbert, Douglas R. Galasko, et al. · Alzheimer s & Dementia · 1

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Interim Analysis Results of Buntanetap in Phase 3 Clinical Studies in Alzheimer’s and Parkinson’s Disease

2023 · Cheng Fang, Melissa Gaines, et al. · Alzheimer s & Dementia · 1

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Works count: 37

Citation count: 1,176

H-index: 14

I10-index: 16