Author

Lorenzo M. Refolo

Observed names: L M Refolo, L. M. REFOLO, L. M. Refolo, L. Refolo, L.M. Refolo, Lorenzo M Refolo, Lorenzo Refolo, Refolo, Lorenzo

Observed institutions: Nathan Kline Institute for Psychiatric Research, National Institutes of Health, Mayo Clinic, Alzheimer's Drug Discovery Foundation, University of California San Diego, National Institute of Neurological Disorders and Stroke, National Institute on Aging, Mayo Clinic in Florida, National Institute of Mental Health, Rutgers New Jersey Medical School, University of Medicine and Dentistry of New Jersey, New York University, Icahn School of Medicine at Mount Sinai

OpenAlex ID: A5113641865

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 · Lorenzo M. Refolo, Miguel A. Pappolla, et al. · Neurobiology of Disease · 1,011

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

2001 · L.M. Refolo, M.A. Pappolla, et al. · Neurobiology of Disease · 530

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

2003 · Etsuro Matsubara, Tara Bryant‐Thomas, et al. · Journal of Neurochemistry · 335

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

2000 · K. Duff, H. Knight, et al. · Neurobiology of Disease · 317

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

2003 · M.A. Pappolla, T.K. Bryant-Thomas, et al. · Neurology · 312

A New Pathogenic Mutation in the APP Gene (I716V) Increases the Relative Proportion of A 42(43)

1997 · C. B. Eckman, N. D. Mehta, et al. · Human Molecular Genetics · 242

Modulation of Aβ peptides by estrogen in mouse models

2001 · H. Zheng, H. Xu, et al. · Journal of Neurochemistry · 175

Statin therapy for Alzheimer’s disease

2002 · Suzana S. Petanceska, Steven DeRosa, et al. · Journal of Molecular Neuroscience · 152

Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

2011 · Diana W Shineman, Guriqbal S Basi, et al. · Alzheimer s Research & Therapy · 139

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Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid β peptide levels

2006 · Javier Pacheco-Quinto, Elena B. Rodriguez de Turco, et al. · Neurobiology of Disease · 120

Cholesterol, oxidative stress, and Alzheimer’s disease: expanding the horizons of pathogenesis1 1This article is part of a series of reviews on “Causes and Consequences of Oxidative Stress in Alzheimer’s Disease.” The full list of papers may be found on the homepage of the journal.

2002 · Miguel A Pappolla, Mark A Smith, et al. · Free Radical Biology and Medicine · 78

Differential brain expression of the Alzheimer's amyloid precursor protein.

1989 · J.P. Anderson, L.M. Refolo, et al. · The EMBO Journal · 76

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Atorvastatin‐induced activation of Alzheimer's α secretase is resistant to standard inhibitors of protein phosphorylation‐regulated ectodomain shedding

2004 · S. Parvathy, Michelle Ehrlich, et al. · Journal of Neurochemistry · 73

The Alzheimer's amyloid precursor protein is produced by type I astrocytes in primary cultures of rat neuroglia

1990 · F. Berkenbosch, L. M. Refolo, et al. · Journal of Neuroscience Research · 62

Bacterial expression, purification, and functional mapping of the amyloid beta/A4 protein precursor.

1992 · J M Roch, I P Shapiro, et al. · Journal of Biological Chemistry · 61

Common Alzheimer's Disease Research Ontology: National Institute on Aging and Alzheimer's Association Collaborative Project

2012 · Lorenzo M. Refolo, Heather Snyder, et al. · Alzheimer s & Dementia · 59

Evidence that secretase cleavage of cell surface Alzheimer amyloid precursor occurs after normal endocytic internalization

1995 · L. M. Refolo, K. Sambamurti, et al. · Journal of Neuroscience Research · 58

Changes in Apolipoprotein E Expression in Response to Dietary and Pharmacological Modulation of Cholesterol

2003 · Suzana S. Petanceska, Steven DeRosa, et al. · Journal of Molecular Neuroscience · 52

Amyloid Precursor Protein Compartmentalization Restricts β-Amyloid Production: Therapeutic Targets Based on BACE Compartmentalization

2004 · Swetal Gandhi, Lorenzo M. Refolo, et al. · Journal of Molecular Neuroscience · 44

International Alzheimer's Disease Research Portfolio (IADRP) aims to capture global Alzheimer's disease research funding

2014 · Charlene Liggins, Heather M. Snyder, et al. · Alzheimer s & Dementia · 32

Study of the phorbol ester effect on Alzheimer amyloid precursor processing: Sequence requirements and involvement of a Cholera toxin sensitive protein

1994 · S. Efthimiopoulos, K. M. Felsenstein, et al. · Journal of Neuroscience Research · 32

Hypercholesterolemia Accelerates the Alzheimer's Amyloid Pathology in a Transgenic Mouse Model

2000 · Lorenzo M. Refolo, Miguel A. Pappolla, et al. · Neurobiology of Disease · 29

Sequence context effects in DNA replication blocks induced by aflatoxin B1.

1985 · L M Refolo, M P Conley, et al. · Proceedings of the National Academy of Sciences · 27

Guidelines to improve animal study design and reproducibility for Alzheimer's disease and related dementias: For funders and researchers

2016 · Heather M. Snyder, Diana W. Shineman, et al. · Alzheimer s & Dementia · 25

The Alzheimer's Amyloid Precursor Is Cleaved Intracellularly in the Trans‐Golgi Network or in a Post‐Golgi Compartment a

1992 · K. SAMBAMURTI, L. M. REFOLO, et al. · Annals of the New York Academy of Sciences · 25

Works count: 64

Citation count: 4,278

H-index: 25

I10-index: 37