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Author

Jörg Czech

Observed names: J CZECH, J Czech, J. Czech, Jorg Czech
Institution: Sanofi (Germany)
OpenAlex ID: A5113658692
Growth Inhibition With Reversible Cell Cycle Arrest of Carcinoma Cells by Flavone L86-8275
1992 · G. Kaur, M. Stetler-Stevenson, et al. · JNCI Journal of the National Cancer Institute · 345
Flavopiridol (L86 8275; NSC 649890), a new kinase inhibitor for tumor therapy
1996 · H Sedlacek, J Czech, et al. · International Journal of Oncology · 276
Tumor-selective prodrug activation by fusion protein-mediated catalysis.
1994 · K Bosslet, J Czech, et al. · PubMed · 125
Probing the Subpockets of Factor Xa Reveals Two Binding Modes for Inhibitors Based on a 2-Carboxyindole Scaffold: A Study Combining Structure-Activity Relationship and X-ray Crystallography
2005 · Marc Nazaré, David W. Will, et al. · Journal of Medicinal Chemistry · 119
A small molecule inhibitor of Nicotinamide N-methyltransferase for the treatment of metabolic disorders
2018 · Aimo Kannt, Sridharan Rajagopal, et al. · Scientific Reports · 103
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Molecular and functional characterisation of a fusion protein suited for tumour specific prodrug activation
1992 · K Bosslet, J Czech, et al. · British Journal of Cancer · 102
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Isolation, Co-Crystallization and Structure-Based Characterization of Anabaenopeptins as Highly Potent Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa)
2016 · Herman Schreuder, Alexander Liesum, et al. · Scientific Reports · 60
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Fragment Deconstruction of Small, Potent Factor Xa Inhibitors: Exploring the Superadditivity Energetics of Fragment Linking in Protein–Ligand Complexes
2011 · Marc Nazaré, Hans Matter, et al. · Angewandte Chemie International Edition · 60
Discovery of N-[4-(1H-Pyrazolo[3,4-b]pyrazin-6-yl)-phenyl]-sulfonamides as Highly Active and Selective SGK1 Inhibitors
2014 · Nis Halland, Friedemann Schmidt, et al. · ACS Medicinal Chemistry Letters · 46
Novel Small Molecule Inhibitors of Activated Thrombin Activatable Fibrinolysis Inhibitor (TAFIa) from Natural Product Anabaenopeptin
2015 · Nis Halland, Mark Brönstrup, et al. · Journal of Medicinal Chemistry · 45
Antitumoral Activity of Flavone L-86-8275
1995 · J CZECH, D HOFFMANN, et al. · International Journal of Oncology · 44
Antibodies as Carriers of Cytotoxicity
1992 · H.H. Sedlacek, G. Seemann, et al. · Beiträge zur Onkologie/Contributions to oncology · 39
Biochemical properties of recombinant human β-glucuronidase synthesized in baby hamster kidney cells
1994 · M C Gehrmann, M Opper, et al. · Biochemical Journal · 35
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Identification of High-Affinity P2Y12Antagonists Based on a Phenylpyrazole Glutamic Acid Piperazine Backbone
2012 · Gernot Zech, Gerhard Hessler, et al. · Journal of Medicinal Chemistry · 34
Custom chemical microarray production and affinity fingerprinting for the S1 pocket of factor VIIa
2004 · Stefan Dickopf, Michael Frank, et al. · Analytical Biochemistry · 32
Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (ADEPT) : A phenol nitrogen mustard carbamate
1997 · F. Schmidt, J.C. Florent, et al. · Bioorganic & Medicinal Chemistry Letters · 32
Pharmacological characterization of a new 4-amidinophenyl-alanine thrombin-inhibitor (CRC 220)
1995 · Gerhard Dickneite, Dirk Seiffge, et al. · Thrombosis Research · 25
Prodrugs of anthracycline antibiotics suited for tumor-specific activation.
1995 · M Azoulay, J C Florent, et al. · PubMed · 22
Factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of neutral P1 substituents
2004 · Marc Nazaré, Melanie Essrich, et al. · Bioorganic & Medicinal Chemistry Letters · 20
Combination of Antibiotic Treatment with the Thrombin Inhibitor Recombinant Hirudin for the Therapy of Experimental Klebsiella pneumoniae Sepsis
1994 · Gerhard Dickneite, Jörg Czech · Thrombosis and Haemostasis · 18
The Change in Research for the Therapy of Tumors
1991 · H.-Harald Sedlacek, Dieter Hoffmann, et al. · CHIMIA International Journal for Chemistry · 17
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Novel factor Xa inhibitors based on a 2-carboxyindole scaffold: SAR of P4 substituents in combination with a neutral P1 ligand
2004 · Marc Nazaré, Melanie Essrich, et al. · Bioorganic & Medicinal Chemistry Letters · 16
Rational Design of Highly Potent, Selective, and Bioavailable SGK1 Protein Kinase Inhibitors for the Treatment of Osteoarthritis
2021 · Nis Halland, Friedemann Schmidt, et al. · Journal of Medicinal Chemistry · 15
Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand
2004 · Marc Nazaré, Hans Matter, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Application of the ADEPT strategy to the MDR resistance in cancer chemotherapy.
1999 · S Desbene, H D Van, et al. · PubMed · 13
Works count: 50
Citation count: 1,746
H-index: 19
I10-index: 30
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