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John J. Talley

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1 H -pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)
1997 · Thomas D. Penning, John J. Talley, et al. · Journal of Medicinal Chemistry · 1,969
Pharmacological analysis of cyclooxygenase-1 in inflammation
1998 · Christopher J. Smith, Yan Zhang, et al. · Proceedings of the National Academy of Sciences · 808
4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2
2000 · John J. Talley, David L. Brown, et al. · Journal of Medicinal Chemistry · 639
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part 2: The second clinical candidate having a shorter and favorable human half-life
2010 · Jane L. Wang, David Limburg, et al. · Bioorganic & Medicinal Chemistry Letters · 338
N -[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration
2000 · John J. Talley, Stephen R. Bertenshaw, et al. · Journal of Medicinal Chemistry · 213
Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere
1993 · Daniel P. Getman, Gary A. DeCrescenzo, et al. · Journal of Medicinal Chemistry · 179
5 Selective Inhibitors of Cyclooxygenase-2 (COT-2)
1999 · John J. Talley · Progress in medicinal chemistry · 178
Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors
1999 · Jeffery S. Carter, Steven Kramer, et al. · Bioorganic & Medicinal Chemistry Letters · 160
Cyanohydrins - a general synthesis
1978 · Paul G. Gassman, John J. Talley · Tetrahedron Letters · 124
Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy
2015 · Scott M. Ebert, Michael C. Dyle, et al. · Journal of Biological Chemistry · 120
Radiosynthesis, in vitro validation, and in vivo evaluation of 18F-labeled COX-1 and COX-2 inhibitors.
2002 · Timothy J McCarthy, Ahmed U Sheriff, et al. · PubMed · 77
Stereospecific intramolecular Diels-Alder reaction of an o-quinone methide
1985 · John J. Talley · The Journal of Organic Chemistry · 63
Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy
2021 · Scott M Ebert, Blake B Rasmussen, et al. · Journal of Nutrition · 57
Synthesis and Evaluation of Novel Erlotinib–NSAID Conjugates as More Comprehensive Anticancer Agents
2015 · Yanmei Zhang, Micky D. Tortorella, et al. · ACS Medicinal Chemistry Letters · 57
Selective inhibitors of cyclooxygenase-2
1997 · John J Talley · Expert Opinion on Therapeutic Patents · 54
The .alpha.-cyano group as a substituent in solvolysis reactions. An evaluation of inductive destabilization vs. mesomeric stabilization of cations by the cyano moiety
1980 · Paul G. Gassman, John J. Talley · Journal of the American Chemical Society · 53
Synthesis of Deuterated Benzopyran Derivatives as Selective COX-2 Inhibitors with Improved Pharmacokinetic Properties
2014 · Yanmei Zhang, Micky D. Tortorella, et al. · ACS Medicinal Chemistry Letters · 49
The novel benzopyran class of selective cyclooxygenase-2 inhibitors-part I: The first clinical candidate
2010 · Jane L. Wang, Jeffery Carter, et al. · Bioorganic & Medicinal Chemistry Letters · 48
Fluorescence Quenching Analysis of the Association and Dissociation of a Diarylheterocycle to Cyclooxygenase-1 and Cyclooxygenase-2: Dynamic Basis of Cyclooxygenase-2 Selectivity
2000 · Cheryl A. Lanzo, Jason Sutin, et al. · Biochemistry · 48
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography
2005 · Tatsushi Toyokuni, J.S. Dileep Kumar, et al. · Bioorganic & Medicinal Chemistry Letters · 46
Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors
1996 · Stephen R. Bertenshaw, John J. Talley, et al. · Bioorganic & Medicinal Chemistry Letters · 42
Reaction of lithium o-lithiophenoxide with carbonyl compounds
1984 · John J. Talley, Irene A. Evans · The Journal of Organic Chemistry · 38
Effect of .alpha.-cyano groups on neighboring group participation in carbonium ion reactions
1980 · Paul G. Gassman, John J. Talley · Journal of the American Chemical Society · 38
The novel benzopyran class of selective cyclooxygenase-2 inhibitors. Part III: The three microdose candidates
2010 · Jane L. Wang, Karl Aston, et al. · Bioorganic & Medicinal Chemistry Letters · 37
4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)
1999 · John J. Talley, Stephen R. Bertenshaw, et al. · Medicinal Research Reviews · 37
Works count: 57
Citation count: 5,791
H-index: 29
I10-index: 36
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