Author

I. E. Garbuzova

Observed names: I.E. Garbuzova, Гарбузова И. Э., Гарбузова Ильмира Эмиргамзаевна, Ильмира Эмиргамзаевна Гарбузова

Institution: Moscow University «Synergy»

Observed institution: Moscow University «Synergy»

ORCID: 0009-0003-9460-4648

Observed ORCID: 0009-0003-9460-4648

OpenAlex ID: A5115529869

Objective: To justify the inclusion of input parameters in a neural network designed to predict rehabilitation measures for patients with pulmonary tuberculosis who have lost their permanent work capacity. Material and methods. The study included 335 patients with pulmonary tuberculosis, 212 with a newly diagnosed case and 123 with a chronic form. To predict the effectiveness of rehabilitation measures, a neural network was developed in the Python 3.14 programming language. Its architecture incorporates a multilayer perceptron with direct connections between neurons and backpropagation algorithms. In the context of this study, it was advisable to use a neural network for predicting permanent disability in patients with pulmonary tuberculosis. Results. The following were integrated as input parameters of the neural network: genotype DD of the GSTM1 gene, genotype EE of the GSTT1 gene, genotype ТС of the АВСВ1 gene and polymorphic variants of cytokine genes, including tumor necrosis factor alpha (–308G>A (rs1800629)), interleukin (IL) 1-beta (–31C>T (rs1143627)), IL-4 (–589C>T) (rs2243250)), IL-10 (–592C>A (rs1800872)), and IL-10 (–1082A>G (rs1800896)). Additionally, an adverse recurrent course, multiple and extensive drug resistance, and persistent respiratory and cardiopulmonary failure following a course of rehabilitation were incorporated. Regression analysis showed the statistical significance of all input parameters with respect to the modeling of the dependent variable. As a result of testing the neural network, the prediction accuracy (rehabilitation efficiency) was 88,3%. Conclusion. The use of a neural network provides highly accurate predictions regarding the effectiveness of rehabilitation of patients with pulmonary tuberculosis. This method can be incorporated into clinical pulmonology practice to evaluate persistent disability in such patients. The presented predictive model is expected to form the basis of a comprehensive rehabilitation program that addresses medical, professional and social aspects.ural networks

2026 · M. A. Alymenko, I. E. Garbuzova, et al. · Реабилитология.

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IFN-γ/IL-10 ratio as an indicator of treatment effectiveness in patients with pulmonary tuberculosis

2025 · M. A. Alymenko, N. P. Balobanova, et al. · HIV Infection and Immunosuppressive Disorders

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Features of cytokine production in patients with pulmonary tuberculosis during specific chemotherapy

2024 · M.A. Alymenko, R.Sh. Valiyev, et al. · JOURNAL of SIBERIAN MEDICAL SCIENCES

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Полиморфизм Гена Фермента Биотрансформации Ксенобиотиков (gstm1) И Особенности Его Клинического Течения У Больных С Туберкулезом Легких

2024 · Алыменко М. А., Валиев Р. Ш., et al. · Таврический медико-биологический вестник

Ассоциация Генотипа Фермента Биотрансформации Ксенобиотика (gstm1) У Больных Туберкулезом Легких С Эффективностью Проведения Интенсивной Фазы Химиотерапии

· Максим Алексеевич Алыменко, Равиль Шамилович Валиев, et al. · CyberLeninK (CyberLeninka)

Works count: 6

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