Concept

Cyclin-dependent kinase 5

OpenAlex ID: C121738310

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

1999 · Gentry N. Patrick, Lawrence Zukerberg, et al. · Nature · 1,558

A decade of CDK5

2001 · Rani Dhavan, Li-Huei Tsai · Nature Reviews Molecular Cell Biology · 1,072

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 · Ming-sum Lee, Young T. Kwon, et al. · Nature · 1,071

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 · Li-Huei Tsai, Ivana Delalle, et al. · Nature · 932

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 · T Ohshima, J M Ward, et al. · Proceedings of the National Academy of Sciences · 903

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

2010 · Jang Hyun Choi, Alexander S. Banks, et al. · Nature · 897

Molecular mechanisms of neurodegeneration in Alzheimer's disease

2010 · L. Crews, E. Masliah · Human Molecular Genetics · 793

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Indirubins Inhibit Glycogen Synthase Kinase-3β and CDK5/P25, Two Protein Kinases Involved in Abnormal Tau Phosphorylation in Alzheimer's Disease

2001 · Sophie Leclerc, Matthieu Garnier, et al. · Journal of Biological Chemistry · 738

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Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 · Teresa Chae, Young T. Kwon, et al. · Neuron · 732

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Lipopolysaccharide-Induced Inflammation Exacerbates Tau Pathology by a Cyclin-Dependent Kinase 5-Mediated Pathway in a Transgenic Model of Alzheimer's Disease

2005 · Masashi Kitazawa, Salvatore Oddo, et al. · Journal of Neuroscience · 724

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Aβ Oligomers Cause Localized Ca 2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

2010 · Hans Zempel, Edda Thies, et al. · Journal of Neuroscience · 719

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Hyperphosphorylation of Microtubule-Associated Protein Tau: A Promising Therapeutic Target for Alzheimer Disease

2008 · C.-X. Gong, K. Iqbal · Current Medicinal Chemistry · 674

Role for neuronal insulin resistance in neurodegenerative diseases

2004 · Markus Schubert, Dinesh Gautam, et al. · Proceedings of the National Academy of Sciences · 659

Tau phosphorylation in neuronal cell function and dysfunction

2004 · Gail V. W. Johnson, William H. Stoothoff · Journal of Cell Science · 657

Aberrant Cdk5 Activation by p25 Triggers Pathological Events Leading to Neurodegeneration and Neurofibrillary Tangles

2003 · Jonathan C. Cruz, Huang-Chun Tseng, et al. · Neuron · 635

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BDNF function and intracellular signaling in neurons.

2010 · Tadahiro Numakawa, Shingo Suzuki, et al. · PubMed · 604

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The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

1996 · M Nikolic, H Dudek, et al. · Genes & Development · 602

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A brain-specific activator of cyclin-dependent kinase 5

1994 · John Lew, Qi-Quan Huang, et al. · Nature · 580

Kinases and phosphatases and tau sites involved in Alzheimer neurofibrillary degeneration

2007 · Jian‐Zhi Wang, Inge Grundke‐Iqbal, et al. · European Journal of Neuroscience · 570

Structural Insights and Biological Effects of Glycogen Synthase Kinase 3-specific Inhibitor AR-A014418

2003 · Ratan Bhat, Yafeng Xue, et al. · Journal of Biological Chemistry · 567

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Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology

2004 · Robert A. Rissman, Wayne W. Poon, et al. · Journal of Clinical Investigation · 566

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Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 · James A. Bibb, Gretchen L. Snyder, et al. · Nature · 566

A Structural Basis for Substrate Specificities of Protein Ser/Thr Kinases: Primary Sequence Preference of Casein Kinases I and II, NIMA, Phosphorylase Kinase, Calmodulin-Dependent Kinase II, CDK5, and Erk1

1996 · Z. Songyang, Kun Ping Lu, et al. · Molecular and Cellular Biology · 553

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

2011 · Jang Hyun Choi, Alexander S. Banks, et al. · Nature · 549

Cdk5 Is a Key Factor in Tau Aggregation and Tangle Formation In Vivo

2003 · Wendy Noble, Vicki Olm, et al. · Neuron · 536

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Works count: 3,283

Citation count: 137,200