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Concept

Perforin

OpenAlex ID: C2776062744
IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity
2001 · Vijay Shankaran, Hiroaki Ikeda, et al. · Nature · 3,079
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
2019 · Weimin Wang, Michael Green, et al. · Nature · 2,911
A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B
1997 · Nancy A. Thornberry, Thomas A. Rano, et al. · Journal of Biological Chemistry · 2,089
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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation
2007 · Hania Kebir, Katharina Kreymborg, et al. · Nature Medicine · 1,811
Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice
1994 · David Kägi, Birgit Ledermann, et al. · Nature · 1,765
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
2003 · Michael R. Betts, Jason M. Brenchley, et al. · Journal of Immunological Methods · 1,589
Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity
1994 · David Kägi, Françoise Vignaux, et al. · Science · 1,544
Perforin and granzymes: function, dysfunction and human pathology
2015 · Ilia Voskoboinik, James C. Whisstock, et al. · Nature reviews. Immunology · 1,410
Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells
1997 · Dörte Hamann, Paul A. Baars, et al. · The Journal of Experimental Medicine · 1,373
Functional significance of the perforin/granzyme cell death pathway
2002 · Joseph A. Trapani, Mark J. Smyth · Nature reviews. Immunology · 1,347
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
2020 · Zhiwei Zhou, Huabin He, et al. · Science · 1,321
Ferroptosis, necroptosis, and pyroptosis in anticancer immunity
2020 · Rong Tang, Jin Xu, et al. · Journal of Hematology & Oncology · 1,292
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Perforin Gene Defects in Familial Hemophagocytic Lymphohistiocytosis
1999 · Susan E. Stepp, Rémi Dufourcq-Lagelouse, et al. · Science · 1,241
CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer.
1998 · Y Naito, K Saito, et al. · PubMed · 1,182
Lymphocyte-Mediated Cytotoxicity
2002 · John H. Russell, Timothy J. Ley · Annual Review of Immunology · 1,153
Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance
2007 · Xuefang Cao, Sheng F. Cai, et al. · Immunity · 1,117
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Human T Regulatory Cells Can Use the Perforin Pathway to Cause Autologous Target Cell Death
2004 · William J. Grossman, James W. Verbsky, et al. · Immunity · 1,104
An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin
1998 · Steffen Stenger, Dennis A. Hanson, et al. · Science · 1,086
Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways
1994 · Bente Lowin, Michael Hahne, et al. · Nature · 1,059
Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues
2013 · Jochem H Bernink, Charlotte P Peters, et al. · Nature Immunology · 1,054
Human MAIT cells are xenobiotic-resistant, tissue-targeted, CD161hi IL-17–secreting T cells
2010 · Mathilde Dusseaux, Emmanuel Martin, et al. · Blood · 1,044
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Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin
2003 · Erika L. Pearce, Alan C. Mullen, et al. · Science · 1,031
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
2002 · Stephen A. Migueles, Alisha C. Laborico, et al. · Nature Immunology · 1,023
Cutting Edge: Contact-Mediated Suppression by CD4+CD25+ Regulatory Cells Involves a Granzyme B-Dependent, Perforin-Independent Mechanism
2005 · David C Gondek, Li-Fan Lu, et al. · The Journal of Immunology · 1,017
Hsp27 negatively regulates cell death by interacting with cytochrome c
2000 · Jean-Marie Bruey, Cécile Ducasse, et al. · Nature Cell Biology · 1,006
Works count: 10,080
Citation count: 422,400
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