Concept

Sparteine

OpenAlex ID: C2778694420

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 · M. Eichelbaum, N. Spannbrucker, et al. · European Journal of Clinical Pharmacology · 634

Enantioselective Synthesis with Lithium/(−)‐Sparteine Carbanion Pairs

1997 · Dieter Hoppe, Thomas Hense · Angewandte Chemie International Edition in English · 627

Geographical/Interracial Differences in Polymorphic Drug Oxidation

1995 · Leif Bertilsson · Clinical Pharmacokinetics · 433

Asymmetric Aldol Additions: Use of Titanium Tetrachloride and (−)-Sparteine for the Soft Enolization of N-Acyl Oxazolidinones, Oxazolidinethiones, and Thiazolidinethiones

2001 · Michael T. Crimmins, Bryan W. King, et al. · The Journal of Organic Chemistry · 387

The genetic polymorphism of debrisoquine/sparteine metabolism — Clinical aspects

1990 · M. Eichelbaum, A.S. Gross · Pharmacology & Therapeutics · 366

Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations

1990 · G. Alv�n, P. Bechtel, et al. · European Journal of Clinical Pharmacology · 358

Oxidation of quinidine by human liver cytochrome P-450.

1986 · F P Guengerich, D Müller-Enoch, et al. · Molecular Pharmacology · 304

Clinical significance of the sparteine/debrisoquine oxidation polymorphism

1989 · K. Br�sen, L. F. Gram · European Journal of Clinical Pharmacology · 281

Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population

1998 · Ernst-Ulrich Griese, Ulrich M. Zanger, et al. · Pharmacogenetics · 280

Chiral Lithium‐1‐oxyalkanides by Asymmetric Deprotonation; Enantioselective Synthesis of 2‐Hydroxyalkanoic Acids and Secondary Alkanols

1990 · Dieter Hoppe, Folker Hintze, et al. · Angewandte Chemie International Edition in English · 250

A Readily-Accessible (+)-Sparteine Surrogate

2002 · Michael J. Dearden, Catherine R. Firkin, et al. · Journal of the American Chemical Society · 242

Codeine and morphine in extensive and poor metabolizers of sparteine: pharmacokinetics, analgesic effect and side effects

1996 · L. Poulsen, K. Brøsen, et al. · European Journal of Clinical Pharmacology · 239

Debrisoquine/Sparteine Hydroxylation Genotype and Phenotype: Analysis of Common Mutations and Alleles of CYP2D6 in a European Population

1991 · F. BROLY, A. GAEDIGK, et al. · DNA and Cell Biology · 217

Pharmacokinetics of Citalopram in Relation to the Sparteine and the Mephenytoin Oxidation Polymorphisms

1993 · S. H. Sindrup, K. Brøsen, et al. · Therapeutic Drug Monitoring · 215

Pharmacogenetics of cytochrome P4502D6: genetic background and clinical implication

2003 · I. Cascorbi · European Journal of Clinical Investigation · 207

The relationship between paroxetine and the sparteine oxidation polymorphism

1992 · Søren H Sindrup, Kim Brøsen, et al. · Clinical Pharmacology & Therapeutics · 205

The influence of environmental and genetic factors on CYP2D6, CYP1A2 and UDP-glucuronosyltransferases in man using sparteine, caffeine, and paracetamol as probes

1994 · Karl Walter Bock, Dieter Schrenk, et al. · Pharmacogenetics · 198

Titanium Enolates of Thiazolidinethione Chiral Auxiliaries: Versatile Tools for Asymmetric Aldol Additions

2000 · Michael T. Crimmins, Kleem Chaudhary · Organic Letters · 196

Inhibition by paroxetine of desipramine metabolism in extensive but not in poor metabolizers of sparteine

1993 · K. Br�sen, J. G. Hansen, et al. · European Journal of Clinical Pharmacology · 192

Competitive inhibition of sparteine oxidation in human liver by β-adrenoceptor antagonists and other cardiovascular drugs

1984 · S.V. Otton, T. Inaba, et al. · Life Sciences · 185

Recent Developments in Hepatic Drug Oxidation

1990 · Kim Brosen · Clinical Pharmacokinetics · 182

In vitro inhibition studies of two isozymes of human liver cytochrome P-450. Mephenytoin p-hydroxylase and sparteine monooxygenase.

1985 · T Inaba, M Jurima, et al. · Drug Metabolism and Disposition · 179

Defective Oxidation of Drugs

1982 · Michel Eichelbaum · Clinical Pharmacokinetics · 176

Asymmetric Deprotonation of N -Boc Piperidine: React IR Monitoring and Mechanistic Aspects

2010 · Darren Stead, Giorgio Carbone, et al. · Journal of the American Chemical Society · 166

Palladium Catalysts for Aerobic Oxidative Kinetic Resolution of Secondary Alcohols Based on Mechanistic Insight

2002 · David R. Jensen, Matthew S. Sigman · Organic Letters · 163

Works count: 1,532

Citation count: 36,650