Concept

Phorbol

OpenAlex ID: C2780043322

Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.

1982 · M Castagna, Y Takai, et al. · Journal of Biological Chemistry · 4,711

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 · Peter Angel, Masayoshi Imagawa, et al. · Cell · 2,871

IκB: a Specific Inhibitor of the NF-κB Transcription Factor

1988 · Patrick A. Baeuerle, David Baltimore · Science · 2,105

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 · Ranjan Sen, David Baltimore · Cell · 1,961

Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.

1989 · M Kobayashi, L Fitz, et al. · The Journal of Experimental Medicine · 1,948

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Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

1983 · D A Bass, J W Parce, et al. · The Journal of Immunology · 1,810

Human cyclooxygenase-2 cDNA.

1992 · T Hla, K Neilson · Proceedings of the National Academy of Sciences · 1,454

Activation of Interleukin-6 Gene Expression through the NF-κB Transcription Factor

1990 · T A Libermann, D Baltimore · Molecular and Cellular Biology · 1,403

Phorbol esters increase the amount of Ca2+, phospholipid-dependent protein kinase associated with plasma membrane

1983 · Andrew S. Kraft, Wayne B. Anderson · Nature · 1,286

Phorbol diester receptor copurifies with protein kinase C.

1983 · J E Niedel, L J Kuhn, et al. · Proceedings of the National Academy of Sciences · 1,168

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 · Y A Hannun, C R Loomis, et al. · Journal of Biological Chemistry · 1,151

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 · U Kikkawa, Y Takai, et al. · Journal of Biological Chemistry · 879

Resveratrol Inhibits Cyclooxygenase-2 Transcription and Activity in Phorbol Ester-treated Human Mammary Epithelial Cells

1998 · Kotha Subbaramaiah, Wen Jing Chung, et al. · Journal of Biological Chemistry · 782

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12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated By an Inducible Enhancer Element Located in the 5′-Flanking Region

1987 · P Angel, I Baumann, et al. · Molecular and Cellular Biology · 694

Cloning and expression of multiple protein kinase C cDNAs

1986 · John L. Knopf, Myung-Ho Lee, et al. · Cell · 653

Crystal structure of the Cys2 activator-binding domain of protein kinase Cδ in complex with phorbol ester

1995 · Gongyi Zhang, Marcelo G Kazanietz, et al. · Cell · 652

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Identification of sphingomyelin turnover as an effector mechanism for the action of tumor necrosis factor alpha and gamma-interferon. Specific role in cell differentiation.

1991 · M Y Kim, C Linardic, et al. · Journal of Biological Chemistry · 631

Optimized THP-1 differentiation is required for the detection of responses to weak stimuli

2007 · E. K. Park, H. S. Jung, et al. · Inflammation Research · 622

Disappearance of Ca2+-sensitive, phospholipid-dependent protein kinase activity in phorbol ester-treated 3T3 cells

1984 · Angeles Rodriguez-Pena, Enrique Rozengurt · Biochemical and Biophysical Research Communications · 612

Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter.

1988 · M Suganuma, H Fujiki, et al. · Proceedings of the National Academy of Sciences · 596

Differences in the state of differentiation of THP-1 cells induced by phorbol ester and 1,25-dihydroxyvitamin D3

1996 · Heike Schwende, Edith Fitzke, et al. · Journal of Leukocyte Biology · 591

Retinoic acid-induced differentiation of cultured human neuroblastoma cells: a comparison with phorbolester-induced differentiation

1984 · Sven Påhlman, Aino-Inkeri Ruusala, et al. · Cell Differentiation · 575

Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters

1988 · Axel Schönthal, Peter Herrlich, et al. · Cell · 562

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 · M Eisinger, O Marko · Proceedings of the National Academy of Sciences · 549

Regulation of endothelial cell gap formation and barrier dysfunction: Role of myosin light chain phosphorylation

1995 · Joe G. N. Garcia, Harold W. Davis, et al. · Journal of Cellular Physiology · 542

Works count: 12,490

Citation count: 425,900