Concept

Toll-Like Receptor 9

OpenAlex ID: C2908999202

A Toll-like receptor recognizes bacterial DNA

2000 · Hiroaki Hemmi, Osamu Takeuchi, et al. · Nature · 6,462

CpG Motifs in Bacterial DNA and Their Immune Effects

2002 · Arthur M. Krieg · Annual Review of Immunology · 2,571

Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition

2001 · Stefan Bauer, Carsten J. Kirschning, et al. · Proceedings of the National Academy of Sciences · 1,529

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

2007 · Jane Tian, Ana Maria Avalos, et al. · Nature Immunology · 1,366

TLR9 signals after translocating from the ER to CpG DNA in the lysosome

2004 · Eicke Latz, Annett Schoenemeyer, et al. · Nature Immunology · 1,355

Therapeutic potential of Toll-like receptor 9 activation

2006 · Arthur M. Krieg · Nature Reviews Drug Discovery · 1,244

Toll-like Receptor 9–mediated Recognition of Herpes Simplex Virus-2 by Plasmacytoid Dendritic Cells

2003 · Jennifer Lund, Ayuko Sato, et al. · The Journal of Experimental Medicine · 1,192

Recognition of pathogen-associated molecular patterns by TLR family

2003 · Shizuo Akira, Hiroaki Hemmi · Immunology Letters · 1,139

Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus

2006 · Sean R. Christensen, Jonathan Shupe, et al. · Immunity · 1,083

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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus

2005 · Franck J. Barrat, Thea Meeker, et al. · The Journal of Experimental Medicine · 924

CpG DNA as a vaccine adjuvant

2011 · Christian Bode, Gan Zhao, et al. · Expert Review of Vaccines · 895

Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9

2005 · Terry K. Means, Eicke Latz, et al. · Journal of Clinical Investigation · 845

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NOD2 is a negative regulator of Toll-like receptor 2–mediated T helper type 1 responses

2004 · Tomohiro Watanabe, Atsushi Kitani, et al. · Nature Immunology · 838

A Toll-like receptor–independent antiviral response induced by double-stranded B-form DNA

2005 · Ken J Ishii, Cevayir Coban, et al. · Nature Immunology · 771

Recognition of Lipopeptide Patterns by Toll-like Receptor 2-Toll-like Receptor 6 Heterodimer

2009 · Jin Young Kang, Xuehua Nan, et al. · Immunity · 770

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Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides

2011 · Jiang Li, Hao Pei, et al. · ACS Nano · 748

TLR9-Dependent Recognition of MCMV by IPC and DC Generates Coordinated Cytokine Responses that Activate Antiviral NK Cell Function

2004 · Anne Krug, Anthony R French, et al. · Immunity · 720

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

2002 · Parviz Ahmad-Nejad, Hans Häcker, et al. · European Journal of Immunology · 714

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Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 · Gregory M Barton, Jonathan C Kagan, et al. · Nature Immunology · 669

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

2008 · Sarah E. Ewald, Bettina L. Lee, et al. · Nature · 615

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Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells

2000 · Gunther Hartmann, Arthur M Krieg · The Journal of Immunology · 601

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

2005 · Andre Bafica, Charles A. Scanga, et al. · The Journal of Experimental Medicine · 595

Characterization of three CpG oligodeoxynucleotide classes with distinct immunostimulatory activities

2003 · Jörg Vollmer, Risini Weeratna, et al. · European Journal of Immunology · 592

Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9

2007 · Peggy Parroche, Fanny N. Lauw, et al. · Proceedings of the National Academy of Sciences · 574

Cutting Edge: Role of Toll-Like Receptor 9 in CpG DNA-Induced Activation of Human Cells

2001 · Fumihiko Takeshita, Cynthia A Leifer, et al. · The Journal of Immunology · 566

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Works count: 1,104

Citation count: 76,940