Get started
Concept

Oligonucleotide synthesis

OpenAlex ID: C68804670
Polymer support oligonucleotide synthesis XVIII1.2): use ofβ-cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product
1984 · N.D. Sinha, J. Biernat, et al. · Nucleic Acids Research · 848
Base composition-independent hybridization in tetramethylammonium chloride: a method for oligonucleotide screening of highly complex gene libraries.
1985 · W I Wood, J Gitschier, et al. · Proceedings of the National Academy of Sciences · 779
Oligonucleotide synthesis : a practical approach
1984 · Michael J. Gait · IRL Press eBooks · 482
Conjugates of oligonucleotides and modified oligonucleotides: a review of their synthesis and properties
1990 · John Goodchild · Bioconjugate Chemistry · 407
The synthesis of oligonucleotides containing an aliphatic amino group at the 5′ terminus: synthesis of fluorescent DNA primers for use in DNA sequence analysis
1985 · Lloyd M. Smith, Steven Fung, et al. · Nucleic Acids Research · 343
Oligonucleotide hybridisations on glass supports: a novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesisedin situ
1992 · Uwe Maskos, Edwin M. Southern · Nucleic Acids Research · 322
Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process
2010 · Emily M. LeProust, Bill J. Peck, et al. · Nucleic Acids Research · 317
PDF
MODIFIED OLIGONUCLEOTIDES: Synthesis and Strategy for Users
1998 · Sandeep Verma, Fritz Eckstein · Annual Review of Biochemistry · 315
In situ synthesis of oligonucleotide microarrays
2004 · Xiaolian Gao, Erdogan Gulari, et al. · Biopolymers · 207
The p-nitrophenylethyl (NPE) group
1984 · Frank Himmelsbach, Bernd S. Schulz, et al. · Tetrahedron · 203
The final deprotection step in oligonucleotide synthesis is reduced to a mild and rapid ammonia treatment by using labile base-protecting groups
1987 · J.C. Schulhof, D. Molko, et al. · Nucleic Acids Research · 200
Rapid synthesis of oligodeoxyribonucleotides VI. Effident, mechanised synthesis of heptadecadeoxyribonucleotides by an improved solid phase phosphotriester route
1981 · Mary Lynn Duckworth, Michael J. Gait, et al. · Nucleic Acids Research · 184
Sustainability Challenges and Opportunities in Oligonucleotide Manufacturing
2020 · Benjamin I. Andrews, Firoz D. Antia, et al. · The Journal of Organic Chemistry · 156
PDF
Internucleotide phosphite sulfurization with tetraethylthiuram disulfide. Phosphorothioate oligonucleotide synthesis via phosphoramidite chemistry
1991 · Huynh Vu, Bernard L. Hirschbein · Tetrahedron Letters · 147
Modification of DNA with Octadiynyl Side Chains: Synthesis, Base Pairing, and Formation of Fluorescent Coumarin Dye Conjugates of Four Nucleobases by the Alkyne−Azide “Click” Reaction
2007 · Frank Seela, Venkata Ramana Sirivolu, et al. · Bioconjugate Chemistry · 144
Fluorescent Nucleoside Analogs: Probes for Investigating Nucleic Acid Structure and Function
2013 · Arun A. Tanpure, Maroti G. Pawar, et al. · Israel Journal of Chemistry · 136
Microfluidic PicoArray synthesis of oligodeoxynucleotides and simultaneous assembling of multiple DNA sequences
2004 · X. Zhou · Nucleic Acids Research · 133
PDF
Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides
2003 · Koji Morita, Miho Takagi, et al. · Bioorganic & Medicinal Chemistry · 131
Efficient activation of nucleoside phosphoramidites with 4,5- dicyanoimidazole during oligonucleotide synthesis
1998 · C Vargeese · Nucleic Acids Research · 130
PDF
Reaction between 1-arenesulphonyl-3-nitro-1,2,4-triazoles and nucleoside base residues. Elucidation of the nature of side-reactions during oligonucleotide synthesis.
1980 · Colin B. Reese, Aiko Ubasawa · Tetrahedron Letters · 130
Syringe method for stepwise chemical synthesis of oligonucleotides
1982 · Toshiki Tanaka, Robert L. Letsinger · Nucleic Acids Research · 125
PDF
Oligonucleotides and Analogues
1991 · 117
Modern approaches to therapeutic oligonucleotide manufacturing
2024 · R. Obexer, M. Nassir, et al. · Science · 115
Synthesis of oligonucleotides on cellulose by a phosphotriester method
1980 · Roberto Crea, Thomas Horn · Nucleic Acids Research · 112
Heterocyclic Modifications of Oligonucleotides and Antisense Technology
2000 · Piet Herdewijn · Antisense and Nucleic Acid Drug Development · 110
Works count: 1,791
Citation count: 26,240
Year
Topic
Type