Get started
Award

Cell Cycle and Podocytes

Description: The studies proposed in this competitive renewal will show novel roles in podo for cdk5 and its partners cyclin I and p35, in the regulation of the slit diaphragm proteins podocin and nephrin, and the actin-regulating proteins podocalyxin and ezrin, and how these are affected in disease.
Funding type: research
Funder scheme: R01
Start date: 2000-05-01
End date: 2016-04-30
Investigator: STUART JAMES SHANKLAND
Institution: UNIVERSITY OF WASHINGTON
Subfield: Nephrology
Field: Medicine
Funded outputs count: 110
Funder award ID: R01DK056799
OpenAlex ID: G6247483170
A single cell atlas of mouse podocytes upon injury identifies kidney zone-dependent responses
2026 · Jeffrey W Pippin, Courtney R. Armour, et al. · bioRxiv (Cold Spring Harbor Laboratory)
PDF
Injury-induced paracrine effects on the podocyte’s transcriptome
2026 · Yuting Zeng, R. Allen Schweickart, et al. · American Journal of Physiology-Renal Physiology · 1
Super-resolved optical imaging, reconstruction, and spatial analysis of whole mouse glomeruli via the Glomerulus Mapping and Analysis Pipeline
2025 · Adilijiang Ali, Zixuan Liu, et al. · Kidney International · 2
Nanoscale Optical Imaging, Reconstruction, and Spatial Analysis of Whole Mouse Glomeruli
2024 · Adilijiang Ali, Zixuan Liu, et al. · bioRxiv (Cold Spring Harbor Laboratory)
A contemporary view of the macula densa: kidney remodeling
2024 · Stuart J. Shankland, Jeffrey W. Pippin, et al. · Kidney International
The tragedy of mitotic catastrophe in podocytes
2024 · Stuart J. Shankland, Behzad Najafian, et al. · Kidney International · 6
Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype
2024 · Sierra R. McKinzie, Natalya Kaverina, et al. · American Journal of Physiology-Renal Physiology · 11
Podocyte Senescence and Aging
2023 · Stuart J. Shankland, Andrew D. Rule, et al. · Kidney360 · 27
Podocyte injury at young age causes premature senescence and worsens glomerular aging
2023 · Beatriz Maria Veloso Pereira, Yuting Zeng, et al. · American Journal of Physiology-Renal Physiology · 22
Inhibiting NLRP3 signaling in aging podocytes improves their life- and health-span
2023 · Natalya Kaverina, R. Allen Schweickart, et al. · Aging · 26
PDF
Repurposing drugs for diseases associated with podocyte dysfunction
2023 · Stuart J. Shankland, J. Ashley Jefferson, et al. · Kidney International · 5
PDF
Loss of epigenetic information as a cause of mammalian aging
2023 · Jae-Hyun Yang, Motoshi Hayano, et al. · Cell · 643
Zoning in on podocytes
2022 · Stuart J. Shankland, Oliver Wessely · Kidney International · 2
Upregulated PD-1 signaling antagonizes glomerular health in aged kidneys and disease
2022 · Jeffrey W. Pippin, Natalya Kaverina, et al. · Journal of Clinical Investigation · 80
PDF
The proliferative and the antifibrotic side of PAX2 in tubular repair
2022 · Oliver Wessely, Stuart J. Shankland · Kidney International · 7
GSKβ as a target in podocyte aging
2022 · Stuart J. Shankland, Oliver Wessely · Kidney International · 1
Podocyte Aging: Why and How Getting Old Matters
2021 · Stuart J. Shankland, Yuliang Wang, et al. · Journal of the American Society of Nephrology · 59
Parietal epithelial cell differentiation to a podocyte fate in the aged mouse kidney
2020 · Natalya V. Kaverina, Diana G. Eng, et al. · Aging · 40
PDF
Global transcriptomic changes occur in aged mouse podocytes
2020 · Yuliang Wang, Diana G. Eng, et al. · Kidney International · 51
Differential expression of parietal epithelial cell and podocyte extracellular matrix proteins in focal segmental glomerulosclerosis and diabetic nephropathy
2019 · Gek Cher Chan, Diana G. Eng, et al. · American Journal of Physiology-Renal Physiology · 36
PDF
Dual lineage tracing shows that glomerular parietal epithelial cells can transdifferentiate toward the adult podocyte fate
2019 · Natalya V. Kaverina, Diana G. Eng, et al. · Kidney International · 61
Erosion of the Epigenetic Landscape and Loss of Cellular Identity as a Cause of Aging in Mammals
2019 · Jae-Hyun Yang, Patrick T. Griffin, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 38
PDF
Sex differences in transcriptomic profiles in aged kidney cells of renin lineage
2018 · Yuliang Wang, Diana G. Eng, et al. · Aging · 17
Detection of renin lineage cell transdifferentiation to podocytes in the kidney glomerulus with dual lineage tracing
2018 · Diana G. Eng, Natalya V. Kaverina, et al. · Kidney International · 41
PDF
Lineage tracing aged mouse kidneys shows lower number of cells of renin lineage and reduced responsiveness to RAAS inhibition
2018 · Hiroko Hamatani, Diana G. Eng, et al. · American Journal of Physiology-Renal Physiology · 14
Year
Topic