Steady state thermodynamic structure for population dynamics and its application
Description: In this work, by introducing the structure of steady-state thermodynamics cultivated in the nonequilibrium statistical physics into cell-growing systems, I revealed that the excess growth generated by environmental changes can be evaluated by Clausius inequality. To be more precise, it was found that the excess growth was bound by lineage fitness which can be observed in an experiment.In the second half of the research, in order to explore the application to an experiment of E. coli, I devised a path integral approach for age-structured population dynamics. Moreover, by employing this approach, I constructed an algorithm for type inference on the lineage tree of E. coli.
Amount: ¥3,900,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Start date: 2016-04-01
End date: 2020-03-31
Investigator: Yuki Sughiyama
Institution: The University of Tokyo
Funded outputs count: 8
Funder award ID: 16K17763
OpenAlex ID: G1033707641