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Radiation-induced astrocyte dysfunction and cognitive decline

Description: NARRATIVE Patients with metastatic brain tumors who are treated with whole brain irradiation (WBI) often experience progressive dementia as a result of this treatment. At the present time, no strategies exist to prevent radiation- induced brain injury and no additional treatments can reverse these effects. Our goal is to understand how radiation damages the brain and to develop effective interventions to maintain learning and memory in these cancer survivors.
Funding type: research
Funder scheme: R01
Start date: 2017-12-01
End date: 2023-11-30
Investigator: ZOLTAN ISTVAN UNGVARI
Institution: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
Field: Medicine
Funded outputs count: 133
Funder award ID: R01NS100782
OpenAlex ID: G5379869209
Time-restricted feeding rejuvenates cerebrovascular function and preserves cognition during aging
2026 · Stefano Tarantini, Madison Milan, et al. · Research Square
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Rethinking dietary fat for the aging brain: the roles or ketosis and fat quality in cerebrovascular aging and VCID
2026 · Sharon Negri, Madison Milan, et al. · Critical Reviews in Food Science and Nutrition
Focused ultrasound opens the blood–brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling
2026 · Sharon Negri, Madison Milan, et al. · Journal of Cerebral Blood Flow & Metabolism · 1
Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood–brain barrier integrity and neurovascular coupling
2026 · Sharon Negri, Madison Milan, et al. · Journal of Cerebral Blood Flow & Metabolism · 1
Long-term cerebrovascular effects of cyclophosphamide and vincristine: endothelial senescence, impaired DNA repair signaling, and blood–brain barrier dysfunction
2026 · Dorina Nagy, Kiana Vali Kordestan, et al. · GeroScience · 1
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Circulating factors as modifiable therapeutic targets in brain and cerebrovascular aging: Insights from heterochronic parabiosis
2026 · Rafal Gulej, Dorina Nagy, et al. · Advances in Translational Research · 5
LDL oxidation and cerebrovascular aging: mechanisms of endothelial dysfunction, inflammation, and vascular cognitive impairment and dementia
2026 · Jennifer Ihuoma, Madison Milan, et al. · Redox Biology · 13
Fasting as Medicine: Mitochondrial and Endothelial Rejuvenation in Vascular Aging
2026 · Madison Milan, Eva Troyano‐Rodriguez, et al. · Aging Cell · 25
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Age-Related Alterations of Cerebral Autoregulation
2025 · Anna Ungvari, Attila Kállai, et al. · Life · 14
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Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries
2025 · Sharon Negri, FENG YAN, et al.
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Optical Coherence Tomography-Based Methodology for In Vivo Visualization and Quantification of Vascular Features and Collagen in Mouse Ovaries
2025 · Sharon Negri, FENG YAN, et al.
PCSK9 expression and cancer survival: a prognostic biomarker at the intersection of oncology and geroscience
2025 · Zoltan Ungvari, Otília Menyhart, et al. · GeroScience · 11
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Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments
2025 · Rafal Gulej, Roland Patai, et al. · GeroScience · 28
Global and tissue-specific transcriptomic dysregulation in human aging: Pathways and predictive biomarkers
2025 · Muhammad Arif, Andrea Lehoczki, et al. · GeroScience · 9
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Sleep disorders increase the risk of dementia, Alzheimer’s disease, and cognitive decline: a meta-analysis
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 56
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Clonal hematopoiesis of indeterminate potential (CHIP) in cerebromicrovascular aging: implications for vascular contributions to cognitive impairment and dementia (VCID)
2025 · Attila Kallai, Anna Ungvari, et al. · GeroScience · 14
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Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 33
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Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 56
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Senescent Endothelial Cells in Cerebral Microcirculation Are Key Drivers of Age‐Related Blood–Brain Barrier Disruption, Microvascular Rarefaction, and Neurovascular Coupling Impairment in Mice
2025 · Boglarka Csik, Ádám Nyúl‐Tóth, et al. · Aging Cell · 44
Cerebromicrovascular senescence in vascular cognitive impairment: does accelerated microvascular aging accompany atherosclerosis?
2025 · Anna Ungvari, Ádám Nyúl-Tóth, et al. · GeroScience · 24
Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity
2025 · Partha Mukhopadhyay, Burhan Yokus, et al. · GeroScience · 16
Persisting blood–brain barrier disruption following cisplatin treatment in a mouse model of chemotherapy-associated cognitive impairment
2025 · Roland Patai, Boglarka Csik, et al. · GeroScience · 35
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Transcriptomic profiling of senescence effects on blood–brain barrier-related gene expression in brain capillary endothelial cells in a mouse model of paclitaxel-induced chemobrain
2025 · Roland Patai, Tamas Kiss, et al. · GeroScience · 24
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The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis
2025 · Mónika Fekete, Péter Varga, et al. · GeroScience · 145
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Impact of adherence to the Mediterranean diet on stroke risk
2025 · Zoltan Ungvari, Mónika Fekete, et al. · GeroScience · 33
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