Adenosine deaminase isoenzymes in Werner syndrome
Description: The pathophysiology of Werner syndrome (WS), the representative hereditary progeroid syndrome, has been suggested to be based on chronic inflammation. On the other hand, adenosine deaminase (ADA), which is a purine nucleotide metabolizing enzyme, has two isozymes, ADA1 and ADA2, and it is known that ADA2 is particularly involved in inflammatory diseases.When serum ADA isozymes activities were measured, ADA2 activity increased with aging in healthy subjects, and WS patients showed the same tendency as elderly patients. This showed the same behavior as high-sensitivity CRP, which is an inflammatory marker. In addition, sugar chain analysis of ADA2 revealed that sugar chains are important for dimer formation and activity expression during the intracellular synthesis process.
Amount: ¥4,290,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2018-04-01
End date: 2021-03-31
Investigator: Sachiko Iwaki-Egawa
Institution: Hokkaido University of Science
Funded outputs count: 1
Funder award ID: 18K08394
OpenAlex ID: G103703103