Integrative metabolomic characterization of ADHD and asthma comorbidity
Description: PROJECT NARRATIVE Although a rich epidemiological literature has demonstrated a high comorbidity between asthma, the most common respiratory disease worldwide, and attention-deficit/hyperactivity disorder (ADHD), the most common behavioral disorder among children, with reports of significant increases in diagnoses in recent years, no studies have interrogated the potential molecular pathobiology underlying the mutual excess risk between asthma and ADHD. This proposal aims to use integrative techniques by combining genetic and metabolomic data to characterize common and distinct mechanisms and pathways of dysregulated metabolism in the presence of comorbid asthma and ADHD and to develop multiomic profiles which can assist in predicting higher risk of ADHD among asthmatic children. The findings from this study will be instrumental in understanding the molecular underpinnings of two highly prevalent public health concerns, and this study will be the first of its kind to interrogate the molecular intersections between asthma and ADHD.
Funding type: career_development
Funder scheme: K01
Start date: 2020-08-01
End date: 2026-06-30
Investigator: SU HEE CHU
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Funded outputs count: 33
Funder award ID: K01HL153941
OpenAlex ID: G5374928609