Award

Mitochondrial Dysfunction in Alzheimer's Disease

Funder: National Institute on Aging

Funding type: research

Funder scheme: R01

Start date: 2001-09-01

End date: 2012-01-31

Investigator: MICHAEL TAI-JU LIN

Institution: WEILL MEDICAL COLL OF CORNELL UNIV

Funded outputs count: 23

Funder award ID: R01AG020729

OpenAlex ID: G1848742955

Neuroprotection by cyclodextrin in cell and mouse models of Alzheimer disease

2012 · Jiaqi Yao, Daniel Ho, et al. · The Journal of Experimental Medicine · 159

Somatic mitochondrial DNA mutations in early parkinson and incidental lewy body disease

2012 · Michael T. Lin, Ippolita Cantuti‐Castelvetri, et al. · Annals of Neurology · 124

Behavioral Improvement after Chronic Administration of Coenzyme Q10 in P301S Transgenic Mice

2012 · Ceyhan Elipenahli, Cliona Stack, et al. · Journal of Alzheimer s Disease · 48

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer's Disease

2011 · Magali Dumont, Khatuna Kipiani, et al. · Journal of Alzheimer s Disease · 161

Impaired β-Amyloid Secretion in Alzheimer's Disease Pathogenesis

2011 · Davide Tampellini, Nawreen Rahman, et al. · Journal of Neuroscience · 41

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High-Resolution 3D Reconstruction Reveals Intra-Synaptic Amyloid Fibrils

2011 · Estibaliz Capetillo-Zarate, Luis Gracia, et al. · American Journal Of Pathology · 31

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2010 · Jiaqi Yao, Tom Hennessey, et al. · PLoS ONE · 93

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Neuroprotective strategies involving ROS in Alzheimer disease

2010 · Magali Dumont, M. Flint Beal · Free Radical Biology and Medicine · 403

Effects of Synaptic Modulation on β-Amyloid, Synaptophysin, and Memory Performance in Alzheimer's Disease Transgenic Mice

2010 · Davide Tampellini, Estibaliz Capetillo-Zarate, et al. · Journal of Neuroscience · 161

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Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

2010 · Tao Ma, Charles A. Hoeffer, et al. · PLoS ONE · 262

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Behavioral deficits and progressive neuropathology in progranulin-deficient mice: a mouse model of frontotemporal dementia

2010 · Fangfang Yin, Magali Dumont, et al. · The FASEB Journal · 180

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Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

2010 · Magali Dumont, Michael T. Lin, et al. · Journal of Alzheimer s Disease · 84

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N-iminoethyl-l-lysine improves memory and reduces amyloid pathology in a transgenic mouse model of amyloid deposition

2009 · Magali Dumont, Elizabeth Wille, et al. · Neurochemistry International · 13

Synaptic Activity Reduces Intraneuronal Aβ, Promotes APP Transport to Synapses, and Protects against Aβ-Related Synaptic Alterations

2009 · Davide Tampellini, Nawreen Rahman, et al. · Journal of Neuroscience · 127

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Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer's disease

2009 · Magali Dumont, Elizabeth Wille, et al. · The FASEB Journal · 221

Triterpenoid CDDO‐methylamide improves memory and decreases amyloid plaques in a transgenic mouse model of Alzheimer’s disease

2009 · Magali Dumont, Elizabeth Wille, et al. · Journal of Neurochemistry · 112

Protection from Alzheimer's-like disease in the mouse by genetic ablation of inducible nitric oxide synthase

2005 · Carl Nathan, Noel Calingasan, et al. · The Journal of Experimental Medicine · 214

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Mitochondria take center stage in aging and neurodegeneration

2005 · M. Flint Beal · Annals of Neurology · 957

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Somatic mitochondrial DNA mutations in single neurons and glia

2004 · Ippolita Cantuti-Castelvetri, Michael T. Lin, et al. · Neurobiology of Aging · 81

Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication

2004 · Pinar E. Coskun, M. Flint Beal, et al. · Proceedings of the National Academy of Sciences · 556

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice

2004 · Feng Li, Noel Y. Calingasan, et al. · Journal of Neurochemistry · 277

Neuroprotective mechanisms of creatine occur in the absence of mitochondrial creatine kinase

2004 · Peter Klivenyi, Noel Y Calingasan, et al. · Neurobiology of Disease · 61

Somatic mitochondrial DNA mutations in cortex and substantia nigra in aging and Parkinson’s disease

2003 · David K Simon, Michael T Lin, et al. · Neurobiology of Aging · 118