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Elucidating the Mechanisms of Translational Approaches to Enhance Recovery of Aged Muscle

Description: PROJECT NARRATIVE Impaired recovery from skeletal muscle disuse in aging results in heightened risk of disability and falls contributing to decreased healthspan. During the F99/K00 phases, I will study the mechanisms of novel therapeutic compounds and cellular interactions to promote muscle recovery in aged mice. This proposal will be guided by a panel of muscle aging experts and training experiences across various disciplines and institutions to promote my training in muscle aging research.
Funding type: fellowship
Funder scheme: F99
Start date: 2021-09-15
End date: 2023-08-31
Investigator: JONATHAN JOSEPH PETROCELLI
Institution: UNIVERSITY OF UTAH
Funded outputs count: 14
Funder award ID: F99AG073493
OpenAlex ID: G4949220299
Stem cell secretome treatment improves whole‐body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice
2024 · Zachary J. Fennel, Paul‐Emile Bourrant, et al. · Aging Cell · 19
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Skeletal muscle-specific inducible AMPKα1/α2 knockout mice develop muscle weakness, glycogen depletion, and fibrosis that persists during disuse atrophy
2023 · Jonathan J. Petrocelli, Jingtong Liu, et al. · American Journal of Physiology-Endocrinology and Metabolism · 10
Treadmill training does not enhance skeletal muscle recovery following disuse atrophy in older male mice
2023 · Elena M. Yee, Carson T. Hauser, et al. · Frontiers in Physiology · 4
Dietary delivery of glycomacropeptide within the whey protein matrix is not effective in mitigating tissue ceramide deposition and obesity in mice fed a high-fat diet
2023 · Naomi M.M.P. de Hart, Jonathan J. Petrocelli, et al. · Journal of Dairy Science · 4
Palmitate-Induced Inflammation and Myotube Atrophy in C2C12 Cells Are Prevented by the Whey Bioactive Peptide, Glycomacropeptide
2023 · Naomi MMP. de Hart, Jonathan J. Petrocelli, et al. · Journal of Nutrition · 12
Disuse‐induced muscle fibrosis, cellular senescence, and senescence‐associated secretory phenotype in older adults are alleviated during re‐ambulation with metformin pre‐treatment
2023 · Jonathan J. Petrocelli, Alec I. McKenzie, et al. · Aging Cell · 72
Lipid hydroperoxides promote sarcopenia through carbonyl stress
2023 · Hiroaki Eshima, Justin L. Shahtout, et al. · eLife · 53
Cellular senescence and disrupted proteostasis induced by myotube atrophy are prevented with low-dose metformin and leucine cocktail
2023 · Jonathan J. Petrocelli, Naomi M.M.P. de Hart, et al. · Aging · 8
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Extracellular vesicle distribution and localization in skeletal muscle at rest and following disuse atrophy
2023 · Ahmed Ismaeel, Douglas W. Van Pelt, et al. · Skeletal Muscle · 21
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Global deletion of CCL2 has adverse impacts on recovery of skeletal muscle fiber size and function and is muscle specific
2023 · Patrick J. Ferrara, Paul T. Reidy, et al. · Journal of Applied Physiology · 12
Muscle disuse as hindlimb unloading in early postnatal mice negatively impacts grip strength in adult mice: a pilot study
2023 · Paul T. Reidy, Austin D. Smith, et al. · Journal of Applied Physiology · 6
Macrophage immunomodulation accelerates skeletal muscle functional recovery in aged mice following disuse atrophy
2022 · Patrick J. Ferrara, Elena M. Yee, et al. · Journal of Applied Physiology · 23
Short-term exposure to a clinical dose of metformin increases skeletal muscle mitochondrial H2O2 emission and production in healthy, older adults: A randomized controlled trial
2022 · Alec I. McKenzie, Ziad S. Mahmassani, et al. · Experimental Gerontology · 14
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From the Model Minority to the Invisible Minority: Asian & Pacific American Students in Higher Education Research. AIR 1998 Annual Forum Paper.
1998 · Jeffrey Rohrlick, Diana Alvarado, et al. · 4
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