Redox regulation in myocardial disease
Description: PUBLIC HEALTH RELEVANCE: Excessive production of free radicals and peroxide, termed reactive oxygen species (ROS), in response to stresses, including high blood pressure and heart attack, causes malfunction and death of heart cells and leads to heart failure in elderly patients. We will investigate how the function of an enzyme termed Nox4, an important source of ROS in the heart, is modulated and how this mechanism affects cardiac damage during cardiac stress. Knowledge obtained from this project should lead to a novel strategy to modify the activity of Nox4, thereby preventing cardiac damage caused by excessive ROS in patients.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2004-02-15
End date: 2020-01-31
Investigator: JUNICHI SADOSHIMA
Institution: RBHS-NEW JERSEY MEDICAL SCHOOL
Funded outputs count: 174
Funder award ID: R01AG023039
OpenAlex ID: G4466128033