The Effects of Physical Disruption on Genome Organization and Integrity
Description: This project investigates how the effects of physical disruptions to cells and DNA, which often affect human health, are related to the three dimensional organization of DNA within the cell nucleus. Understanding how genome organization affects chromosomal rearrangements that can occur after DNA breakage will help explain the origin and progression of cancers that are often caused or affected by these rearrangements. Measuring the effects of other forces and stresses felt by the cell on genome organization will provide information about how forces on cells in human tissues and organs can affect their proper development and function.
Funding type: fellowship
Funder scheme: F32
Start date: 2012-02-01
End date: 2014-01-31
Investigator: RACHEL PATTON MCCORD
Institution: UNIV OF MASSACHUSETTS MED SCH WORCESTER
Funded outputs count: 9
Funder award ID: F32GM100617
OpenAlex ID: G2901697605