The mediating role of Slow Wave Sleep and Vascular Risk Factors on Alzheimer Disease related disparity between African-Americans and non-Hispanic Whites
Description: Project Narrative/Relevance to Public Health Alzheimer’s disease (AD) disproportionately affects Black/African American older adults who have significantly less slow wave sleep (SWS) duration and higher prevalence of vascular risk factors (VRFs), both of which increase Alzheimer’s disease risk, and are associated with AD biomarkers in cognitive normal subjects. More importantly, identifying possible race-related biologic mechanisms driving AD disparities and asymptomatic blacks at higher risk of cognitive decline from AD is crucial to preventing its onset among blacks. The long-term goal of this K23 is for Dr. Bubu to become an independent investigator who identifies pertinent modifiable and possible race-related biologic mechanisms for AD expression e.g. SWS and VRFs, in order to develop strategies for intervention in the hopes to increase sleep quality, and control vascular risk factors as novel therapeutic targets for Alzheimer’s disease prevention in blacks.
Funder: National Institute on Aging
Funding type: career_development
Funder scheme: K23
Start date: 2021-05-15
End date: 2026-04-30
Investigator: OMONIGHO A MICHAEL BUBU
Institution: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
Funded outputs count: 46
Funder award ID: K23AG068534
OpenAlex ID: G9000916734