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The Role of Somatic Transposition in Age-associated Genomic Instability

Description: Project Narrative Retrotransposable element (RTE) DNA sequences are parasitic, mobile, and normally repressed DNA elements that can insert into new genomic positions using a “copy and paste” mechanism. Recently, it was discovered that retrotransposable elements become active in cellular senescence and aging. The goal of this proposal is to characterize the detrimental consequences of RTE derepression in cellular senescence and to assess whether RTEs may be damaging to the genome of somatic cells during aging.
Funding type: research
Funder scheme: R01
Start date: 2017-09-15
End date: 2024-04-30
Investigator: NICOLA NERETTI
Institution: BROWN UNIVERSITY
Subfield: Plant Science
Funded outputs count: 19
Funder award ID: R01AG050582
OpenAlex ID: G7870123639
Senescence-Associated Chromatin Rewiring Promotes Inflammation and Transposable Element Activation
2025 · Audrey Dalgarno, Shane A. Evans, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 5
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SenNet recommendations for detecting senescent cells in different tissues
2024 · Vidyani Suryadevara, Adam D. Hudgins, et al. · Nature Reviews Molecular Cell Biology · 409
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Single-Cell Transcriptomics Reveals Global Markers of Transcriptional Diversity across Different Forms of Cellular Senescence
2023 · Nicola Neretti, Shane A. Evans, et al. · 13
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LINE-1 retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5′ single-cell RNA-Seq
2023 · Wilson McKerrow, Larisa Kagermazova, et al. · Nucleic Acids Research · 30
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Single-cell transcriptomics of peripheral blood in the aging mouse
2023 · Yee Voan Teo, Samuel J. Hinthorn, et al. · Aging · 28
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Single-cell analysis of the aging female mouse hypothalamus
2022 · Kaitlyn H. Hajdarovic, Doudou Yu, et al. · Nature Aging · 116
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Translational Significance of the LINE-1 Jumping Gene in Skeletal Muscle
2022 · Matthew A. Romero, Petey W. Mumford, et al. · Exercise and Sport Sciences Reviews · 4
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
2021 · Anthony Lagnado, Jack Leslie, et al. · The EMBO Journal · 211
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Toward a Three-Dimensional Chromosome Shape Alphabet
2021 · Carlos Soto, Darshan Bryner, et al. · Journal of Computational Biology · 5
The functional impact of nuclear reorganization in cellular senescence
2021 · Azucena Rocha, Audrey Dalgarno, et al. · Briefings in Functional Genomics · 38
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Whole‐body senescent cell clearance alleviates age‐related brain inflammation and cognitive impairment in mice
2021 · Mikolaj Ogrodnik, Shane A. Evans, et al. · Aging Cell · 402
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Towards A 3D Chromosome Shape Alphabet
2020 · Carlos Soto, Darshan Bryner, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Single cell RNA‐seq in the sea urchin embryo show marked cell‐type specificity in the Delta/Notch pathway
2019 · Stephany Foster, Yee Voan Teo, et al. · Molecular Reproduction and Development · 17
Notch Signaling Mediates Secondary Senescence
2019 · Yee Voan Teo, Nattaphong Rattanavirotkul, et al. · Cell Reports · 149
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Notch signalling mediates secondary senescence
2019 · Yee Voan Teo, Nattaphong Rattanavirotkul, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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L1 drives IFN in senescent cells and promotes age-associated inflammation
2019 · Marco De Cecco, Takahiro Ito, et al. · Nature · 1,255
Cell‐free DNA as a biomarker of aging
2018 · Yee Voan Teo, Miriam Capri, et al. · Aging Cell · 152
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The three-dimensional organization of the genome in cellular senescence and age-associated diseases
2018 · Shane A. Evans, Jeremy Horrell, et al. · Seminars in Cell and Developmental Biology · 28
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Research on Deep Coal Seam Mining Floor Starta Water Bursting Influenced Factors Based on Analytic Hierachy Process
2014 · Sun, Ming Ming, et al. · International Journal of Technology Management
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