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Modulation of liver fibrosis resolution by dendritic cells

Description: Liver fibrosis, or scarring, is an important public health problem, affecting millions of individuals worldwide who have chronic liver disease. We will study how specific immune cells, named dendritic cells, accelerate fibrosis resolution and recovery following liver injury. This application will open a new avenue for modifying the natural history of fibrosis regression, possibly leading to the testing of dendritic cell therapy to reduce fibrosis in patients with liver disease.
Funding type: career_development
Funder scheme: K08
Start date: 2011-07-15
End date: 2017-06-30
Investigator: COSTICA ALOMAN
Institution: RUSH UNIVERSITY MEDICAL CENTER
Subfield: Hepatology
Field: Medicine
Funded outputs count: 17
Funder award ID: K08DK088954
OpenAlex ID: G1634447736
Imprinted immune abnormalities in liver transplant patients cured of hepatitis C with antiviral drugs
2024 · Erin H. Doyle, Costica Aloman, et al. · Liver Transplantation
Recipient risk factors for acute cellular rejection after orthotopic liver transplant ‐ a single‐center, retrospective study
2020 · David Choi, Mengyuan Liu, et al. · Transplant International · 4
Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease
2017 · Fernando Magdaleno, Xiaodong Ge, et al. · Hepatology Communications · 16
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Diurnal variations in intestinal barrier integrity and liver pathology in mice: implications for alcohol binge
2017 · Robin M. Voigt, Christopher B. Forsyth, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 26
Overactivation of intestinal sterol response element-binding protein 2 promotes diet-induced nonalcoholic steatohepatitis
2017 · Pooja Malhotra, Costica Aloman, et al. · American Journal of Physiology-Gastrointestinal and Liver Physiology · 12
Interleukin-15 receptor α on hepatic stellate cells regulates hepatic fibrogenesis in mice
2016 · Jingjing Jiao, Kohtaro Ooka, et al. · Journal of Hepatology · 39
Increased hepatic progenitor cell response and ductular reaction in patients with severe recurrent HCV post‐liver transplantation
2016 · Seth N. Sclair, Maria Isabel Fiel, et al. · Clinical Transplantation · 12
The dynamic and clinical significance of autoantibodies and immunoglobulins in liver transplant recipients
2015 · Carmen M. Stanca, Costica Aloman, et al. · Clinical Transplantation · 4
β-PDGF receptor expressed by hepatic stellate cells regulates fibrosis in murine liver injury, but not carcinogenesis
2015 · Peri Kocabayoglu, Abigale Lade, et al. · Journal of Hepatology · 184
Inhibition of the CXCL 12/ CXCR 4 chemokine axis with AMD 3100, a CXCR 4 small molecule inhibitor, worsens murine hepatic injury
2014 · Yedidya Saiman, JingJing Jiao, et al. · Hepatology Research · 40
Central Role of Conventional Dendritic Cells in Regulation of Bone Marrow Release and Survival of Neutrophils
2014 · Jingjing Jiao, Ana-Cristina Dragomir, et al. · The Journal of Immunology · 51
Medullary thymic epithelial cell depletion leads to autoimmune hepatitis
2013 · Anthony J. Bonito, Costica Aloman, et al. · Journal of Clinical Investigation · 74
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Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice
2013 · Jean-Philippe Pradere, Johannes Kluwe, et al. · Hepatology · 612
Dendritic cells and liver fibrosis
2013 · Adeeb H. Rahman, Costica Aloman · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 73
A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice
2012 · Juan E. Puche, Youngmin A. Lee, et al. · Hepatology · 136
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GM-CSF Controls Nonlymphoid Tissue Dendritic Cell Homeostasis but Is Dispensable for the Differentiation of Inflammatory Dendritic Cells
2012 · Melanie Greter, Julie Helft, et al. · Immunity · 431
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Dendritic Cells in Alcoholic Liver Injury and Fibrosis
2011 · Costica Aloman, Scott L. Friedman, et al. · Alcoholism Clinical and Experimental Research · 11
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