O-GlcNAcylation regulates vascular smooth muscle cells in diabetic vasculopathy
Description: PUBLIC HEALTH RELEVANCE: This proposal will focus on elucidating novel molecular mechanisms underlying O-GlcNAcylation-regulated vascular smooth muscle cell phenotype and osteogenic differentiation that contribute to diabetic vasculopathy. We have demonstrated that increased O-GlcNAcylation was associated with vascular calcification in diabetic arteries from human and mice; and a direct effect of O-GlcNAcylation in regulating smooth muscle cell calcification in vitro; the proposed studies will determine a definitive role of O-GlcNAcylation-regulated molecular signals in regulating vascular calcification in diabetes with tissue-specific knockout mice. Our studies will provide important molecular insights into the function of O-GlcNAcylation in regulating diabetic vasculopathy, which will lead to the development of novel strategy or drugs for prevention and therapy of these diabetic complications.
Funding type: research
Funder scheme: R01
Start date: 2014-04-01
End date: 2019-02-28
Investigator: YABING CHEN
Institution: UNIVERSITY OF ALABAMA AT BIRMINGHAM
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 14
Funder award ID: R01DK100847
OpenAlex ID: G2599562498