Lifecourse sleep, cognitive decline and risk of Alzheimer's disease: a pooled cohort study.
Description: PROJECT NARRATIVE Leveraging rich data resources from seven well-characterized longitudinal cohorts, we propose to use a cutting-edge life course approach to determine the impact of objective and subjective sleep disturbances from different stages of life on cognitive trajectories across the life course. This novel research will help elucidate the role of life-course sleep disturbance as a prodromal or modifiable risk factor for Alzheimer's disease, which can directly inform the early detection of Alzheimer's and design of future sleep intervention trials. Moreover, the creation of a unique synthesized diverse cohort of life-course sleep and cognition will establish foundational resources for future research that aims to unravel the bi-directional link between sleep and Alzheimer's disease.
Funder: National Institute on Aging
Funding type: research
Funder scheme: R01
Start date: 2024-05-15
End date: 2029-02-28
Investigator: YUE LENG
Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
Funded outputs count: 16
Funder award ID: R01AG083836
OpenAlex ID: G9000883346