Analysis on molecular nutritional functions of bile acids as a feeding signal, and regulation of metabolic response to feeding by food factors
Description: Bile acids are secreted into the upper small intestine upon ingestion, and then taken up in the lower small intestine and returned to the liver. Since a portion of bile acids flow into the systemic bloodstream, the bile acid concentration in the blood increases after eating, which is considered to be a feeding signal. The target molecule that recognizes this is the bile acid receptor TGR5. For functional analysis in skeletal muscle, transgenic mice expressing human TGR5 in skeletal muscle were established and analyzed. It was found that activation of TGR5 by bile acid resulted in a muscle hypertrophy effect. When an oral glucose tolerance test was performed, a rapid decrease in blood glucose was confirmed, and it was clarified that an increase in muscle mass leads to an improvement in glucose intolerance. Part of the increase in muscle mass associated with the feeding response may be due to TGR5 function.
Amount: ¥192,000,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (S)
Start date: 2015-05-29
End date: 2020-03-31
Investigator: Ryuichiro Sato
Institution: The University of Tokyo
Funded outputs count: 21
Funder award ID: 15H05781
OpenAlex ID: G120861270