Maternal Obesity and aging cause a sex specific adverse effects on lipid metabolism and inflammation in offspring
Description: Maternal metabolic profile during pregnancy and later affects the metabolic profile of their offspring. During the pregnancy, lipid metabolism undergoes complex changes to accommodate for the increased requirements. Pathological changes in the lipid metabolism represents the hallmark of many metabolic diseases, therefore, to understand the lipid metabolism during the pregnancy is of utmost importance to set the foundation for healthier pregnancies and healthier postnatal life. To achieve the project objectives we will investigate several hypothesis: A) Parental transmission of predisposition to obesity-related disorders to their offspring and which pathological changes in lipid metabolism could be translated to offspring and if these changes could be attenuated by dietary intervention with DHA, B) Influence of long-term effects of high-calorie/ low-calorie diet during rodent development on the lipid metabolism and onset of metabolic diseases in connection to specific sex related metabolic responses and differences that could have important health consequences. C) Maternal metabolic status can predispose differently female and male offspring to metabolic diseases resulting in sex specific responses to obesity. D) The influence of specific changes in lipid metabolism, inflammation and oxidative status that develops in aging mothers, independently, or in the combination with obesity that could cause alterations in the metabolism of F1 and F2 generations.Finally, data from the whole project will result in the integration of gained knowledge from all experiments and in better understanding of complexity of changes of lipid metabolism in the pregnancies of obese and aged mothers and whether these maternal effects persist for several generations. Integrative approach will allow us to suggest new approaches for development and implementation of preventative measures to improve outcomes of the pregnancies affected by obesity and age.
Funder: Hrvatska Zaklada za Znanost
Amount: €132,700
Funding type: grant
Funder scheme: IP
Start date: 2023-12-21
End date: 2027-12-20
Investigator: Kristina Starčević
Institution: University of Zagreb, Faculty of Veterinary Medicine
Funded outputs count: 1
Funder award ID: IP-2022-10-4578
OpenAlex ID: G122052613